Abstract
The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.
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Kerr, L., Ransone, L., Wamsley, P. et al. Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB. Nature 365, 412–419 (1993). https://doi.org/10.1038/365412a0
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DOI: https://doi.org/10.1038/365412a0
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