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Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

Nature volume 365, pages 314–320 (1993)Cite this article

Abstract

Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.

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Authors and Affiliations

  1. Neurobiologie des Fonctions Rythmiques et Saisonnieres, CNRS URA 1332, Université Louis Pasteur, 12 rue de I'Université, 67000, Strasbourg, France

    Jërg H. Stehle, Valérie Simonneaux & Paul Pévet

  2. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U184 de I'lNSERM, Faculté de Médecine, 11 rue Humann, 67085, Strasbourg, France

    Nicholas S. Foulkes, Carlos A. Molina & Paolo Sassone-Corsi

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  1. Jërg H. Stehle
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  2. Nicholas S. Foulkes
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  4. Valérie Simonneaux
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Stehle, J., Foulkes, N., Molina, C. et al. Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. Nature 365, 314–320 (1993). https://doi.org/10.1038/365314a0

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