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Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

Nature volume 365, pages 253–255 (1993)Cite this article

Abstract

CILIARY neurotrophic factor (CNTF) promotes the survival of several populations of neurons, including sensory and motor neurons1—4. Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; there-fore, it has been proposed to act as a lesion factor3. The identifica-tion of a functional CNTF receptor revealed ligand-specific phosphorylation cascades and gene induction5. However, it is not clear how these signal-transducing events are elicited in neuronal cell bodies that may be distant from the source of CNTF. We report here that CNTF can be retrogradely transported by adult sensory neurons. More importantly, sensory and motor neurons both show greatly increased transport of CNTF following periph-eral nerve lesion. Axotomy-induced increases in retrograde trans-port of neurotrophic factors may be an important response of neuronal cell bodies during regeneration.

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References

  1. Barbin, G., Manthorpe, M. & Varon, S. J. Neurochem. 43, 1468–1478 (1984).

    Article  CAS  Google Scholar 

  2. Arakawa, Y., Sendtner, M. & Thoenen, H. J. Neurosci. 10, 3507–3515 (1990).

    Article  CAS  Google Scholar 

  3. Thoenen, H. Trends Neurosci. 14, 165–170 (1991).

    Article  CAS  Google Scholar 

  4. Oppenheim, R. W., Prevette, D., Qin-Wei, Y., Collins, F. & MacDonald, J. Science 251, 1616–1618 (1991).

    Article  ADS  CAS  Google Scholar 

  5. Ip, N. Y. et al. Cell 69, 1121–1132 (1992).

    Article  CAS  Google Scholar 

  6. Stöckli, K. A. et al. Nature 342, 920–923 (1989).

    Article  ADS  Google Scholar 

  7. Ip, N. Y. et al. Neuron 10, 89–102 (1993).

    Article  CAS  Google Scholar 

  8. Davis, S. et al. Science 253, 59–63 (1991).

    Article  ADS  CAS  Google Scholar 

  9. Davis, S. et al. Science 259, 1736–1739 (1993).

    Article  ADS  CAS  Google Scholar 

  10. Gearing, D. P. et al. Science 255, 1434–1437 (1992).

    Article  ADS  CAS  Google Scholar 

  11. Taga, T. et al. Cell 58, 573–581 (1989).

    Article  CAS  Google Scholar 

  12. Johnson, E. M., Taniuchi, M. & DiStefano, P. S. Trends Neurosci. 7, 299–304 (1988).

    Article  Google Scholar 

  13. Friedman, B. et al. Neuron 9, 295–305 (1992).

    Article  CAS  Google Scholar 

  14. Sendtner, M., Stöckli, K. A. & Thoenen, H. J. Cell Biol. 118, 139–148 (1992).

    Article  CAS  Google Scholar 

  15. Seniuk, N., Altares, M., Dunn, R. & Richardson, P. M. Brain Res. 572, 300–302 (1992).

    Article  CAS  Google Scholar 

  16. Hendry, I. A., Stöckel, K., Thoenen, H. & Iversen, L. L. Brain Res. 68, 103–121 (1974).

    Article  CAS  Google Scholar 

  17. DiStefano, P. S. et al. Neuron 8, 983–993 (1992).

    Article  CAS  Google Scholar 

  18. Ferguson, I. A., Schweitzer, J. B., Bartlett, P. F. & Johnson, E. M. J. comp. Neurol. 313, 680–692 (1991).

    Article  CAS  Google Scholar 

  19. Hansson, H.-A., Rozell, B. & Skottner, A. Cell Tiss. Res. 247, 241–247 (1987).

    Article  CAS  Google Scholar 

  20. Meyer, M., Matsuoka, I., Wetmore, C., Olson, L. & Thoenen, H. J. Cell Biol. 119, 45–54 (1992).

    Article  CAS  Google Scholar 

  21. Sendtner, M., Kreutzberg, G. W. & Thoenen, H. Nature 345, 440–441 (1990).

    Article  ADS  CAS  Google Scholar 

  22. Sendtner, M. et al. Nature 358, 502–504 (1992).

    Article  ADS  CAS  Google Scholar 

  23. Helgren, M. et al. Soc. Neurosci. Abstr. 18, 618 (1992).

    Google Scholar 

  24. Holmlund, T. H. et al. Neurology 42 (suppl. 3), 369 (1992).

    Google Scholar 

  25. Masiakowski, P. et al. J. Neurochem. 57, 1003–1012 (1991).

    Article  CAS  Google Scholar 

  26. Marchalonis, J. J. Biochem. J. 113, 299–305 (1969).

    Article  CAS  Google Scholar 

  27. Chomczynski, P. & Sacchi, N. Analyt. Biochem. 162, 156–159 (1987).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York, 10591, USA

    Rory Curtis, Krystyna M. Adryan, Yuan Zhu, Peter J. Harkness, Ronald M. Lindsay & Peter S. DiStefano

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  1. Rory Curtis
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  2. Krystyna M. Adryan
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  3. Yuan Zhu
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  4. Peter J. Harkness
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  5. Ronald M. Lindsay
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  6. Peter S. DiStefano
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Curtis, R., Adryan, K., Zhu, Y. et al. Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Nature 365, 253–255 (1993). https://doi.org/10.1038/365253a0

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