Abstract
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein klnases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ATP complex have been determined to 2.4Å resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix—loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.
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De Bondt, H., Rosenblatt, J., Jancarik, J. et al. Crystal structure of cyclin-dependent kinase 2. Nature 363, 595–602 (1993). https://doi.org/10.1038/363595a0
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DOI: https://doi.org/10.1038/363595a0
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