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Molecular characterization of the Arabidopsis floral homeotic gene APETALA1

Nature volume 360, pages 273–277 (1992)Cite this article

Abstract

THE first step in flower development is the transition of an inflorescence meristem into a floral meristem. Each floral meristem differentiates into a flower consisting of four organ types that occupy precisely defined positions within four concentric whorls. Genetic studies in Arabidopsis thaliana and Antirrhinum majus have identified early-acting genes that determine the identity of the floral meristem, and late-acting genes that determine floral organ identity1–5. In Arabidopsis, at least two genes, APETALA1 and LEAFY, are required for the transition of an inflorescence meristem into a floral meristem1. We have cloned the APETALA1 gene and here we show that it encodes a putative transcription factor that contains a MADS-domain2. APETALA1 RNA is uniformly expressed in young flower primordia, and later becomes localized to sepals and petals. Our results suggest that APETALA1 acts locally to specify the identity of the floral meristem, and to determine sepal and petal development.

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References

  1. Weigel, D., Alvarez, J., Smyth, D. R., Yanofsky, M. F. & Meyerowitz, E. M. Cell 69, 843–859 (1992).

    Article  CAS  Google Scholar 

  2. Schwarz-Sommer, Z., Huijser, P., Nacken, W., Saedler, H. & Sommer, H. Science 250, 931–936 (1990).

    Article  ADS  CAS  Google Scholar 

  3. Coen, E. S. & Meyerowitz, E. M. Nature 353, 31–37 (1991).

    Article  ADS  CAS  Google Scholar 

  4. Coen, E. S. et al. Cell 63, 1311–1322 (1990).

    Article  CAS  Google Scholar 

  5. Bowman, J. L., Smyth, D. R. & Meyerowitz, E. M. Development 112, 1–20 (1991).

    CAS  Google Scholar 

  6. Koornneef, M. et al. J. Hered. 74, 265–272 (1983).

    Article  Google Scholar 

  7. Irish, V. F. & Sussex, I. M. P. Cell 2, 741–753 (1990).

    Article  CAS  Google Scholar 

  8. Sommer, H. et al. EMBO J. 9, 605–613 (1990).

    Article  CAS  Google Scholar 

  9. Yanofsky, M. F. et al. Nature 346, 35–39 (1990).

    Article  ADS  CAS  Google Scholar 

  10. Huijser, P. et al. EMBO J. 11, 1239–1249 (1992).

    Article  CAS  Google Scholar 

  11. Jack, T., Brockman, L. L. & Meyerowitz, E. M. Cell 68, 683–697 (1992).

    Article  CAS  Google Scholar 

  12. Norman, C., Runswick, M. & Pollock, R. Cell 55, 989–1003 (1988).

    Article  CAS  Google Scholar 

  13. Passmore, S., Maine, G. T., Elble, R., Christ, C. & Tye, B. K. J. molec. Biol. 204, 593–606 (1988).

    Article  CAS  Google Scholar 

  14. Hayes, T. E., Sengupta, P. & Cochran, B. H. Genes Dev. 2, 1713–1722 (1988).

    Article  CAS  Google Scholar 

  15. Mueller, C. G. F. & Nordheim, A. EMBO J. 10, 4219–4229 (1991).

    Article  CAS  Google Scholar 

  16. Schwarz-Sommer, Z. et al. EMBO J. 11, 251–263 (1992).

    Article  CAS  Google Scholar 

  17. Ma, H., Yanofsky, M. F. & Meyerowitz, E. M. Genes Dev. 5, 484–495 (1991).

    Article  CAS  Google Scholar 

  18. Chang, C., Bowman, J. L., De John, A. W., Lander, E. S. & Meyerowitz, E. M. Proc. natn. Acad. Sci. U.S.A. 85, 6856–6860 (1988).

    Article  ADS  CAS  Google Scholar 

  19. Steinert, P. M. & Roop, D. R. A. Rev. Biochem. 57, 593–625 (1988).

    Article  CAS  Google Scholar 

  20. Elledge, S. J., Mulligan, J. T., Ramer, S. W., Spottswood, M. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 88, 1731–1735 (1991).

    Article  ADS  CAS  Google Scholar 

  21. Crawford, N. M., Campbell, W. H. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 83, 8073–8076 (1986).

    Article  ADS  CAS  Google Scholar 

  22. Smyth, D. R., Bowman, J. L. & Meyerowitz, E. M. Pl. Cell 2, 755–767 (1990).

    Article  CAS  Google Scholar 

  23. Drews, G. N., Bowman, J. L. & Meyerowitz, E. M. Cell 65, 991–1002 (1991).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biology and Center for Molecular Genetics, University of California at San Diego, La Jolla, California, 92093-0116, USA

    M. Alejandra Mandel, Cindy Gustafson-Brown, Beth Savidge & Martin F. Yanofsky

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  1. M. Alejandra Mandel
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  2. Cindy Gustafson-Brown
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  3. Beth Savidge
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  4. Martin F. Yanofsky
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Alejandra Mandel, M., Gustafson-Brown, C., Savidge, B. et al. Molecular characterization of the Arabidopsis floral homeotic gene APETALA1. Nature 360, 273–277 (1992). https://doi.org/10.1038/360273a0

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