Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The ACE of hearts

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout


  1. Cambien, F. et al. Nature 359, 641–644 (1992).

    Article  ADS  CAS  Google Scholar 

  2. Cooper, D. N. & Clayton, J. F. Hum. Genet. 78, 299–312 (1988).

    Article  CAS  Google Scholar 

  3. Pfeffer, M. A. et al. New Engl. J. Med. 327, 669–677 (1992).

    Article  CAS  Google Scholar 

  4. Hirsch, A. T., Talsness, C. E., Schunkert, H., Paul, M. & Dzau, V. J. Circ. Res. 69, 475–482 (1991).

    Article  CAS  Google Scholar 

  5. Berg, K. in Genetic Approaches to Coronary Heart Disease and Hypertension (eds Berg, K., Bulyzhenkov, V., Christen, Y. & Corvol, P.) Vol. 1, 98–109 (Springer, Berlin, 1991).

    Google Scholar 

  6. Urata, H., Healy, B., Stewart, R. W., Bumpus, F. M. & Husain, A. Circ. Res. 66, 883–890 (1990).

    Article  CAS  Google Scholar 

  7. Swales, J. D. & Dzau, V. J. Am. Heart J. 123, 1412–1413 (1992).

    Article  CAS  Google Scholar 

  8. Jacob, H. J. et al. Cell 67, 213–224 (1991).

    Article  CAS  Google Scholar 

  9. Hilbert, P. et al. Nature 353, 521–529 (1991).

    Article  ADS  CAS  Google Scholar 

  10. Jeunemaitre, X., Lifton, R. P., Hunt, S. C., Williams, R. R. & Lalouel, J. M. Nature Genet. 1, 72–75 (1992).

    Article  CAS  Google Scholar 

  11. O'Rourke, M. Hypertension 15, 339–347 (1990).

    Article  CAS  Google Scholar 

  12. Safar, M. E. J. Hypertension 7, 769–776 (1989).

    Article  CAS  Google Scholar 

  13. Jeunemaitre, X. et al. Cell 71, 169–180 (1992).

    Article  CAS  Google Scholar 

  14. Laragh, J. H. Hypertension 20, 267–279 (1992).

    Article  CAS  Google Scholar 

  15. Rigat, B. et al. J. clin. Invest. 86, 1343–1346 (1990).

    Article  CAS  Google Scholar 

  16. Swales, J. D. & Heagerty, A. M. J. Hypertension 5, (suppl. 2), s1–s5 (1987).

    Article  CAS  Google Scholar 

  17. Costerousse, O., Allegrini, J., Lopez, M. & Alhenc-Gelas, F. Biochem. J. (in the press).

  18. Bodmer, W. F. Cold Spring Harb. Symp. quant. Biol. 51, 1–13 (1986).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kurtz, T. The ACE of hearts. Nature 359, 588–589 (1992).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing