Abstract
The speed and throughput of DNA sequencing can be increased by performing sequencing separations on arrays of microcapillaries followed by detection with a laser-excited, confocal-fluorescence scanner.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hunkapiller, T., Kaiser, R. J., Koop, B. F. & Hood, L. Science 254, 59–67 (1991).
Karger, B. L. Nature 339, 641–642 (1989).
Smith, L. M. Nature 349, 812–813 (1991).
Swerdlow, H. et al. Analyt. Chem. 63, 2835–2841 (1991).
Luckey, J. A. et al. Nucleic Acids Res. 18, 4417–4421 (1990).
Cohen, A. S., Najarian, D. R. & Karger, B. L. J. Chromatogr. 516, 49–60 (1990).
Quesada, M. A., Rye, H. S., Gingrich, J. C., Glazer, A. N. & Mathies, R. A. Bio Techniques 10, 616–625 (1991).
Rye, H. S. et al. Nucleic Acids Res. 20, 2803–2812 (1992).
Rye, H. S., Quesada, M. A., Peck, K., Mathies, R. A. & Glazer, A. N. Nucleic Acids Res. 19, 327–333 (1991).
Glazer, A. N., Peck, K. & Mathies, R. A. Proc. natn. Acad. Sci. U.S.A. 87, 3851–3855 (1990).
Huang, X. C., Quesada, M. A. & Mathies, R. A. Analyt. Chem. 64, 967–972 (1992).
Heiger, D. N., Cohen, A. S. & Karger, B. L. J. Chromatogr. 516, 33–48 (1990).
Smith, L. M. et al. Nature 321, 674–679 (1986).
Tabor, S. & Richardson, C. C. J. biol. Chem. 265, 8322–8328 (1990).
Pentoney, S. L. & Konrad, K. D. Proc. CLEO/QELS, 94 (Anaheim, California, May 10–15, 1992).
Huang, X. C., Quesada, M. A. & Mathies, R. A. Analyt. Chem. 64, 2149–2154 (1992).
Kostichka, A. J., Marchbanks, M. L., Brumley, R. L., Drossman, H. & Smith, L. M. Bio/Technology 10, 78–81 (1992).
Schwartz, H. E. & Ulfelder, K. J. Analyt. Chem. 64, 1737–1740 (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mathies, R., Huang, X. Capillary array electrophoresis: an approach to high-speed, high-throughput DNA sequencing. Nature 359, 167–169 (1992). https://doi.org/10.1038/359167a0
Issue Date:
DOI: https://doi.org/10.1038/359167a0
This article is cited by
-
Network approach to understand biological systems: From single to multilayer networks
Journal of Biosciences (2022)
-
Oct4 dependent chromatin activation is required for chicken primordial germ cell migration
Stem Cell Reviews and Reports (2022)
-
Investigation the Effect of Additive Content and Sintering Temperature on the Mechanical Properties of Clay-Bonded and Glass-Bonded Ceramic Parts Produced by Low Injection Molding Method
Silicon (2022)