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Mapping antibody binding sites on protein antigens

Nature volume 356, pages 456–457 (1992)Cite this article

The large surfaces of protein antigens that interact with antibody-combining sites can be determined using deuterium-exchange labelling and two-dimensional 1H nuclear magnetic resonance (NMR). This technique may also be applied to other protein-protein interactions to identify key residues that contribute to the affinity.

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  1. Department of Microbiology, School of Medicine, University of Pennsylvania, 209 Johnson Pavilion, Philadelphia, Pennsylvania, 19104-6076, USA

    Yvonne Paterson

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  1. Yvonne Paterson
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Paterson, Y. Mapping antibody binding sites on protein antigens. Nature 356, 456–457 (1992). https://doi.org/10.1038/356456a0

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