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Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

Nature volume 354, pages 453–459 (1991)Cite this article

Abstract

In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.

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Author notes

  1. Jonathan A. Rothbard: Immulogic, Palo Alto, California 94304, USA

  2. Charles R. Rizza: Oxford Haemophilia Centre, Churchill Hospital, Oxford OX3 7LV, UK

Authors and Affiliations

  1. Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Rodney E. Phillips, Sarah Rowland-Jones, Douglas F. Nixon, Frances M. Gotch, Jon P. Edwards, Afolabi O. Ogunlesi, John G. Elvin, Jonathan A. Rothbard, Charles R. M. Bangham, Charles R. Rizza & Andrew J. McMichael

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  1. Rodney E. Phillips
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  2. Sarah Rowland-Jones
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  3. Douglas F. Nixon
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  4. Frances M. Gotch
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  5. Jon P. Edwards
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  6. Afolabi O. Ogunlesi
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  7. John G. Elvin
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  8. Jonathan A. Rothbard
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  11. Andrew J. McMichael
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Phillips, R., Rowland-Jones, S., Nixon, D. et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354, 453–459 (1991). https://doi.org/10.1038/354453a0

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  • DOI: https://doi.org/10.1038/354453a0

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