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Peripheral deletion of self-reactive B cells

Nature volume 354, pages 308–311 (1991)Cite this article

Abstract

B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted1–4. Developing B cells that react with membrane antigens expressed in the bone marrow are deleted from the peripheral lymphocyte pool4–6. It is important to ascertain the fate of B cells that recognize membrane autoantigens expressed exclusively on peripheral tisues because B cells in the peripheral lymphoid organs are phenotypically and functionally distinct from bone-marrow B cells7–9. Here we show that in immunoglobulin-transgenic mice, B cells specific for major histocompatibility complex class I antigen can be deleted if they encounter membrane-bound antigen at a post-bone-marrow stage of development. This deletion may be necessary to prevent organ-specific autoimmunity.

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References

  1. Nossal, G. J. V. Science 24, 147–153 (1989).

    Article  ADS  Google Scholar 

  2. Goodnow, C. C. et al. Nature 334, 676–682 (1988).

    Article  ADS  CAS  Google Scholar 

  3. Erikson, J. et al. Nature 349, 331–334 (1991).

    Article  ADS  CAS  Google Scholar 

  4. Nemazee, D. & Bürki, K. Nature 337, 562–566 (1989).

    Article  ADS  CAS  Google Scholar 

  5. Nemazee, D. & Bürki, K. Proc natn. Acad Sci. U.S.A. 86, 8039–8043 (1989).

    Article  ADS  CAS  Google Scholar 

  6. Nemazee, D. et al. Immunol. Rev. 122, 117–132 (1991).

    Article  CAS  Google Scholar 

  7. Raff, M. C. et al. J. exp. Med. 142, 1052–1064 (1975).

    Article  CAS  Google Scholar 

  8. Sidman, C. L. & Unanue, E. R. Nature 257, 149–151 (1975).

    Article  ADS  CAS  Google Scholar 

  9. Gu, H., Tarlington, D., Müller, W., Rajewsky, K. & Förster, I. J. exp. Med. 173, 1357–1371 (1991).

    Article  CAS  Google Scholar 

  10. Morahan, G. et al. Proc. natn. Acad. Sci. U.S.A. 86, 3782–3786 (1989).

    Article  ADS  CAS  Google Scholar 

  11. Vitetta, E. S., Cambier, J. C., Ligler, F. S., Kettman, J. R. & Uhr, J. W. J. exp. Med. 146, 1804–1810 (1977).

    Article  CAS  Google Scholar 

  12. Scott, D. W., Layton, J. E. & Nossal, G. V. J. J. exp. Med. 146, 1473–1483 (1977).

    Article  CAS  Google Scholar 

  13. Tisch, R., Roifman, C. M. & Hozumi, N. Proc. natn. Acad. Sci. U.S.A. 85, 6914–6918 (1988).

    Article  ADS  CAS  Google Scholar 

  14. Alés-Martínez, J. E., Warner, G. L. & Scott, D. W. Proc. Natn. Acad. Sci. U.S.A. 85, 6919–6923 (1988).

    Article  ADS  Google Scholar 

  15. Rammensee, H.-G., Bevan, M. J. & Fink, P. J. Immun. Today 6, 41–43 (1985).

    Article  CAS  Google Scholar 

  16. Chestnut, R. W. & Grey, H. M. J. Immun. 115, 1075–1079 (1981).

    Google Scholar 

  17. Ron, Y. & Sprent, J. J. immun. 128, 2848–2856 (1987).

    Google Scholar 

  18. Nakamura, R. M., Voller, A. & Bidwell, D. E. in Handbook of Experimental Immunology 4th edn (eds Weir, D. M., Herzenberg, I. A., Blackwell, C. C. & Herzenberg, L. A.) 26.1–27.20 (Blackwell, London, 1986).

    Google Scholar 

  19. Leptin, M. et al. Eur. J. Immun. 13, 534–542 (1984).

    Article  Google Scholar 

  20. Nemazee, D. A. in Proc. EMBO Workshop on Tolerance (eds Matzinger, P. et al.) Vol. 2 52–54 (Editiones Roche, Basel, 1987).

    Google Scholar 

  21. Coffman, R. L. & Weissman, I. L. Nature 289, 681–683 (1981).

    Article  ADS  CAS  Google Scholar 

  22. Ozato, K., Mayer, N. & Sachs, D. H. J. Immun. 124, 533–540 (1980).

    CAS  PubMed  Google Scholar 

  23. Dembiċ, Z. et al. Nature 320, 232–238 (1986).

    Article  ADS  Google Scholar 

  24. Grosveld, F. G. et al. Nucleic Acids Res. 10, 67145–6732? (1982).

    Google Scholar 

  25. Sieckman, D. Fed. Proc. 43, 488 (1987).

    Google Scholar 

  26. Stall, A. M. & Loken, M. R. J. Immun. 132, 787–795 (1984).

    CAS  Google Scholar 

  27. Hardy, R. R. in Handbook of Experimental Immunology 4th edn (eds Weir, D. M., Herzenberg, L. A., Blackwell, C. C. & Herzenberg, L. A.) 97.1–97.17 (Blackwell, London, 1986).

    Google Scholar 

  28. Steinmetz, M. et al. Cell 25, 125–134 (1981).

    Article  Google Scholar 

  29. Jones, D. T. & Reed, R. R. J. biol. Chem. 262, 13241–14249 (1987).

    Google Scholar 

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Author notes

  1. David Nemazee: To whom correspondence should be addressed

Authors and Affiliations

  1. Division of Basic Sciences, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson Street, Denver, Colorado, 80206, USA

    David M. Russell & David Nemazee

  2. Department of Molecular Biology, Hoffmann-La Roche, CH-4005, Basel, Switzerland

    Zlatko Dembić

  3. Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria, 3050, Australia

    Grant Morahan & J. F. A. P. Miller

  4. Department of Biotechnology, Sandoz, CH-4002, Basel, Switzerland

    Kurt BÜrki

  5. Department of Microbiology and Immunology, University of Colorado Health Sciences Center, Denver, Colorado, 80206, USA

    David Nemazee

Authors
  1. David M. Russell
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  2. Zlatko Dembić
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  3. Grant Morahan
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  4. J. F. A. P. Miller
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  5. Kurt BÜrki
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  6. David Nemazee
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Russell, D., Dembić, Z., Morahan, G. et al. Peripheral deletion of self-reactive B cells. Nature 354, 308–311 (1991). https://doi.org/10.1038/354308a0

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