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Solid-phase gene assembly

Naturevolume 352pages548549 (1991) | Download Citation

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New technologies for multiple chemical synthesis of oligonucleotides and stepwise hybridization on a solid-phase support enable the rapid and cost-effective preparation of long duplex DNA regions. Will these new technologies usher in a new era in protein engineering?

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Author notes

  1. Kenneth L. Beattie: Commercial development of the multiple DNA synthesis and solid-phase gene assembly technologies is taking place at Genosys Biotechnologies, Inc., 8701 New Trails Drive, The Woodlands, Texas 77381, USA.

Affiliations

  1. Center for Biotechnology, Baylor College of Medicine, 4000 Research Forest Drive, The Woodlands, Texas, 77381, USA

    • Kenneth L. Beattie
    •  & Richard F. Fowler
  2. also employed by the Houston Advanced Research Center, 4800 Research Forest Drive, The Woodlands, Texas, 77381, USA

    • Kenneth L. Beattie

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https://doi.org/10.1038/352548a0

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