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Detection of human carcinogens

Rodent cancer bioassays are no longer the most efficient way to detect possible human carcinogens. A more imaginative approach is needed.

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References

  1. Ames, B. N. & Gold, L. S. Science 249, 970–971 (1990).

    Article  ADS  CAS  Google Scholar 

  2. Ames, B. N. & Gold, L. S. Proc. natn. Acad. Sci. U.S.A. 87, 7772–7776 (1990).

    Article  ADS  CAS  Google Scholar 

  3. Hay, A. Nature 350, 555–556 (1991).

    Article  ADS  CAS  Google Scholar 

  4. Peto, R. in Assessment of risk from low-level exposure to radiation and chemicals (eds Woodhead, A. D., Shellabarger, C. J., Pond, V. & Hollaender, A. 3–16 (Plenum, London, 1985).

    Book  Google Scholar 

  5. Cagliano, V. J. et al. Science 251, 606–608 (1991).

    Article  ADS  Google Scholar 

  6. Weinstein, I. B. Science 251, 387–388 (1991).

    Article  ADS  CAS  Google Scholar 

  7. Mailing, H. V. & Chu, E. H. Y. in Chemical Carcinogenesis (eds Tsos, P. O. P. & Di Paolo, J. A.) (Dekker, New York, 1974).

    Google Scholar 

  8. Weisburger, J. H. & Williams, G. M. Fdn Chem. Toxic. 19, 561–566 (1981).

    Article  CAS  Google Scholar 

  9. Butterworth, B. E. Mut. Res. 239, 117–132 (1990).

    Article  CAS  Google Scholar 

  10. Clayson, D. B. & Arnold, D. L. Mut. Res. 257, 91–106 (1991).

    Article  CAS  Google Scholar 

  11. Bartsch H. & Malaveille, C. Cell Biol. Toxic. 5, 115 (1989).

    Article  CAS  Google Scholar 

  12. Shelby, M. D. & Zeiger, E. Mut. Res. 234, 257 (1991).

    Article  Google Scholar 

  13. Griesemer R. A. Mut. Res. 257, 207 (1991).

    Article  Google Scholar 

  14. Huff, J. E., Salmon, A. G., Hooper, N. K. & Zeise, L. Cell. Biol. Toxic. 7, 67–94 (1991).

    Article  CAS  Google Scholar 

  15. Roberts, L. Science 252, 911 (1991).

    Article  ADS  CAS  Google Scholar 

  16. Ashby, J. & Tennant, R. W. Mut. Res. 257, 229–306 (1991).

    Article  CAS  Google Scholar 

  17. Bridges, B. Mut. Res. 41, 71–72 (1976).

    Article  Google Scholar 

  18. Ashby, J. Mutagenesis 1, 3–16 (1986).

    Article  CAS  Google Scholar 

  19. Cohen, S. M. & Ellwein, L. B. Science 249, 1007 (1990).

    Article  ADS  CAS  Google Scholar 

  20. Yarnasaki, H. & Fitzgerald, D. J. in Tumour Promoters (ed. Langenbach, R.) (Raven, New York, 1988).

    Google Scholar 

  21. Hill, R. N. et al. Fund. Appl. Toxic. 12, 629 (1989).

    Article  CAS  Google Scholar 

  22. Dietrich, D. R. & Swenberg, J. A. Mut. Res. 248, 239–260 (1991).

    Article  CAS  Google Scholar 

  23. Clayson, D. B. Mut. Res. 221, 53–67 (1989).

    Article  CAS  Google Scholar 

  24. Haseman, J. K. & Huff, J. E. Cancer Lett. 37, 125–132 (1987).

    Article  CAS  Google Scholar 

  25. Tennant, R. W. et al. Mutagenesis 5, 3 (1990).

    Article  CAS  Google Scholar 

Download references

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Ashby, J., Morrod, R. Detection of human carcinogens. Nature 352, 185–186 (1991). https://doi.org/10.1038/352185a0

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