Abstract
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
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Stover, C., de la Cruz, V., Fuerst, T. et al. New use of BCG for recombinant vaccines. Nature 351, 456–460 (1991). https://doi.org/10.1038/351456a0
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DOI: https://doi.org/10.1038/351456a0
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