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Male development of chromosomally female mice transgenic for Sry

Abstract

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

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Koopman, P., Gubbay, J., Vivian, N. et al. Male development of chromosomally female mice transgenic for Sry. Nature 351, 117–121 (1991). https://doi.org/10.1038/351117a0

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