Abstract
T LYMPHOCYTES recognize antigen in the form of peptides that associate with specific alleles of class I or class II major histo-compatibility (MHC) molecules1,2. By contrast with the clear MHC allele-specific binding of peptides to purified class II molecules3–6 purified solubilized class I molecules either bind relatively poorly7 or show degenerate specificity8–11. Using photo-affinity labelling, we demonstrate here the specific interaction of peptides with cell-associated MHC class I molecules and show that this involves metabolically active processes.
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Luescher, I., Romero, P., Cerottini, JC. et al. Specific binding of antigenic peptides to cell-associated MHC class I molecules. Nature 351, 72–74 (1991). https://doi.org/10.1038/351072a0
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DOI: https://doi.org/10.1038/351072a0
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