Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Ion channels

Accessory to kidney disease

Nature volume 414, pages 502–503 (2001)Cite this article

The protein that is mutated in a human disorder of the kidney and ear turns out to be an accessory subunit for a chloride ion channel. The discovery explains the symptoms of the disease.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Ion transport in the kidney.
Figure 2: Ion transport in the inner ear.

References

  1. Bartter, F. C., Pronove, P., Gill, J. R. Jr & MacCardle, R. C. J. Am. Soc. Nephrol. 9, 516–528 (1998).

    CAS  PubMed  Google Scholar 

  2. Landau, D., Shalev, H., Ohaly, M. & Carmi, R. Am. J. Med. Genet. 59, 454–459 (1995).

    Article  CAS  Google Scholar 

  3. Birkenhager, R. et al. Nature Genet. 29, 310–314 (2001).

    Article  CAS  Google Scholar 

  4. Estévez, R. et al. Nature 414, 558–561 (2001).

    Article  ADS  Google Scholar 

  5. Greger, R. Physiol. Rev. 65, 760–793 (1985).

    Article  ADS  CAS  Google Scholar 

  6. Scheinman, S. J., Guay-Woodford, L. M., Thakker, R. V. & Warnock, D. G. New Engl. J. Med. 340, 1177–1187 (1999).

    Article  CAS  Google Scholar 

  7. Wangemann, P. H. & Schacht, J. in The Cochlea (eds Dallos, P., Popper, A. N. & Fry, R. R.) 130–185 (Springer, New York, 1996).

  8. Matsumura, Y. et al. Nature Genet. 21, 95–98 (1999).

    Article  CAS  Google Scholar 

  9. Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, MA, 2001).

Download references

Author information

Authors and Affiliations

  1. the School of Biomedical Sciences, Worsley Medical and Dental Building, University of Leeds, Leeds, LS2 9NQ, UK

    Malcolm Hunter

Authors
  1. Malcolm Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Malcolm Hunter.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hunter, M. Accessory to kidney disease. Nature 414, 502–503 (2001). https://doi.org/10.1038/35107186

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35107186

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing