Extending the lifespan of long-lived mice


Ames dwarf mice are mutant mice that live about 50% longer than their normal siblings1,2,3 because they carry a 'longevity' gene, Prop1df, and in some phenotypic respects they resemble normal mice whose lifespan has been extended by restricted food intake2,4,5. Here we investigate whether these factors influence lifespan by similar or independent mechanisms, by deliberately reducing the number of calories consumed by Ames dwarf mice. We show that calorie restriction confers a further lifespan increase in the dwarfs, indicating that the two factors may act through different pathways.

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  1. 1

    Brown-Borg, H. M., Borg, K. E., Meliska, C. J. & Bartke, A. Nature 384, 33 (1996).

  2. 2

    Bartke, A. in The Molecular Genetics of Aging (ed. Hekimi, S.) Vol. 29, 181–202 (Springer, New York, 2000).

  3. 3

    Flurkey, K., Papaconstantinou, J., Miller, R. A. & Harrison, D. E. Proc Natl Acad. Sci. USA 98, 6736–6741 (2001).

  4. 4

    Harris, S. B., Gunion, M. W., Rosenthal, M. J. & Walford, R. L. Mech. Ageing Dev. 73, 209–221 (1994).

  5. 5

    Weindruch, R. Toxicol. Pathol. 24, 742–745 (1996).

  6. 6

    Mattison, J. A. et al. J. Am. Aging Assoc. 23, 9–16 (2000).

  7. 7

    Coschigano, K. T., Clemmons, D., Bellush, L. L. & Kopchick, J. J. Endocrinology 141, 2608–2613 (2000).

  8. 8

    Clancy, D. J. et al. Science 292, 104–106 (2001).

  9. 9

    Tatar, M. et al. Science 292, 107–110 (2001).

  10. 10

    Kimura, K. D., Tissenbaum, H. A., Liu, Y. & Ruvkun, G. Science 277, 942–946 (1997).

  11. 11

    Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M. & Longo, V. D. Science 292, 288–290 (2001).

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Correspondence to Andrzej Bartke.

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