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Genome sequencing networks

Nature Reviews Genetics volume 2, pages 979–983 (2001)Cite this article

Abstract

Genome sequencing projects have been undertaken in one of three ways: in a purpose-built and professionally staffed genome centre, by a small number of traditional research laboratories or by an extensive network of traditional research laboratories that are linked by the Internet. Sequencing networks are an attractive option in many circumstances as they are easy to create, bring together diverse types of expertise, integrate the eventual users of a genome sequence with its determination and generally foster a collaborative spirit.

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Figure 1: The principal steps involved in generating a complete genome sequence.
Figure 2: A conceptual diagram of the flux of work and information in a network-based genome-sequencing project.

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Acknowledgements

I thank the hundreds of scientists, students and associates who have made genomics such a telling reality in Brazil. In addition, I thank F. Perez (Scientific Director of FAPESP), L. Old (Scientific Director of the Ludwig Institute) and R. Brentani (Director of the São Paulo Branch of the Ludwig Institute) for their continuing support and encouragement, and without whom network-based genome sequencing would not have been established in the state of São Paulo. I am also grateful to O. Caballero and A. Vettore for their critical reading of this manuscript. The sequencing of X. fastidiosa, X. citri, X. campestris, and L. xyli has been funded principally by FAPESP, and the national genome project to sequence C. violaceum has been coordinated and funded exclusively by the Ministério de Ciência e Tecnologia (MCT) in conjunction with Conselho Nacional de Desenvolvimento Cíentifico de Tecnológico (CNPq).

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  1. Laboratory of Cancer Genetics, Ludwig Institute for Cancer Research, Rua Professor Antônio Prudente, 109, 4th floor, São Paulo, 01509-010, SP, Brazil

    Andrew J. G. Simpson

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  1. Andrew J. G. Simpson
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FURTHER INFORMATION

TIGR Comprehensive Microbial Resource

Dedicated sequencing centres

Genoscope

Kasuza DNA Research Institute

TIGR

The Sanger Centre

Sequencing consortia

Brazilian genome virtual institute of genomic research

ONSA

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Simpson, A. Genome sequencing networks. Nat Rev Genet 2, 979–983 (2001). https://doi.org/10.1038/35103503

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