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Molecular markers in CNS stem cell research: hitting a moving target

Nature Reviews Neuroscience volume 2, pages 843–846 (2001)Cite this article

Abstract

The study of neural stem cell biology is hindered by the absence of well-defined markers for neural stem cells and neuronal progenitors. Without the ability to identify the relevant cell types, the analysis of how the diverse cell populations of the central nervous system are generated becomes virtually impossible.

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Figure 1: The complexity of neural cell lineage.
Figure 2: Our strategy to discover CNS stem and progenitor cell genes.

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Acknowledgements

The authors are suppoted by the US National Institute of Mental Health. We thank M. Easterday for helpful comments.

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Authors and Affiliations

  1. the Department of Molecular and Medical Pharmacology, the Department of Pediatrics and the Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, 90095, USA, California

    Harley I. Kornblum

  2. member of the Program in Neurogenetics and Department of Neurology, UCLA School of Medicine, Los Angeles, 90095, California, USA

    Daniel H. Geschwind

Authors
  1. Harley I. Kornblum
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  2. Daniel H. Geschwind
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Corresponding author

Correspondence to Harley I. Kornblum.

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DATABASES

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FGF

GFAP

musashi

nestin

β-tubulin III

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Kornblum, H., Geschwind, D. Molecular markers in CNS stem cell research: hitting a moving target. Nat Rev Neurosci 2, 843–846 (2001). https://doi.org/10.1038/35097597

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