The human brain continues to develop for some time after birth, providing an opportunity for experience to influence neural development. In the first few years after birth, both brain volume and cognitive function increase markedly.
Although most neurons are in place by birth, synaptogenesis occurs at a high rate during the first year of life, and the number of synapses peaks during this period at ∼150% of adult levels. Brain activity patterns change during this time and most myelination is postnatal. Such changes occur at different times for different brain areas.
Young infants fail in some cognitive tasks, such as reaching for an occluded object (up to 9 months) or detecting a change in an object passing behind a surface. Although other abilities seem to be adult-like at this stage, visual object processing appears to develop fully only by the second year of life. Very young infants are predisposed to look at faces, and this bias may assist in the development of social processing abilities.
Three theories of functional brain development are proposed. The maturational perspective states that cognitive abilities develop as the cortical areas mediating them mature. The interactive specialization approach suggests that cognitive abilities develop as the networks of cortical areas that mediate them develop appropriate interactions. The skill-learning hypothesis proposes that certain regions will be active during the development of skills in infants, but that other regions will be active once the skill has been learned (as in adult motor learning).
There is some evidence for each of these theories, and they are not mutually exclusive. Functional brain development in human infants depends on experience and neural activity as well as brain maturation.
There is a continuing debate in developmental neuroscience about the importance of activity-dependent processes. The relatively delayed rate of development of the human brain, compared with that of other mammals, might make it more susceptible to the influence of postnatal experience. The human infant is well adapted to capitalize on this opportunity through primitive biases to attend to relevant stimuli in its environment. The infant's interaction with its environment helps to sculpt inter- and intraregional connections within the cortex, eventually resulting in the highly specialized adult brain.
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Johnson, M. H. Into the minds of babes. Science 286, 247 (1999).
Finlay, B. L. & Darlington, R. B. Linked regularities in the development and evolution of mammalian brains. Science 268, 1578–1584 (1995).
Clancy, B., Darlington, R. B. & Finlay, B. L. The course of human events: predicting the timing of primate neural development. Dev. Sci. 3, 57–66 (2000).
Born, P. et al. Change of visually induced cortical activation patterns during development. Lancet 347, 543 (1996).
Yamada, H. et al. A rapid brain metabolic change in infants detected by fMRI. Neuroreport 8, 3775–3778 (1997).
Yamada, H. et al. A milestone for normal development of the infantile brain detected by functional MRI. Neurology 55, 218–223 (2000).
Eriksson, P. S. et al. Neurogenesis in the adult human hippocampus. Nature Med. 4, 1313–1317 (1998).
Spreen, O., Risser, A. T. & Edgell, D. Developmental Neuropsychology (Oxford Univ. Press, New York, 1995).
Huttenlocher, P. R. Morphometric study of human cerebral cortex development. Neuropsychologia 28, 517–527 (1990).
Huttenlocher, P. R. & Dabholkar, A. S. in Development of the Prefrontal Cortex: Evolution, Neurobiology, and Behavior (eds Krasnegor, N. A., Lyon, G. R. & Goldman-Rakic, P. S.) 69–84 (Paul. H. Brookes, Baltimore, 1997).
Bourgeois, J. P. in Handbook of Developmental Cognitive Neuroscience (eds Nelson, C. A. & Luciana, M.) 23–34 (MIT Press, Boston, 2001).
Chugani, H. T., Phelps, M. E. & Mazziotta, J. C. Positron emission tomography study of human brain functional development. Ann. Neurol. 22, 487–497 (1987).
Huttenlocher, P. R. et al. Synaptogenesis in human visual cortex: evidence for synapse elimination during normal development. Neurosci. Lett. 33, 247–252 (1982).
Matsuzawa, J. et al. Age-related volumetric changes of brain gray and white matter in healthy infants and children. Cereb. Cortex 11, 335–342 (2001).
Paus, T. et al. Maturation of white matter in the human brain: a review of magnetic resonance studies. Brain Res. Bull. 54, 255–266 (2001).
Pfefferbaum, A. et al. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch. Neurol. 51, 874–887 (1994).
Giedd, J. N. et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neurosci. 2, 861–863 (1999).
Haith, M. M. Who put the cog in infant cognition? Is the rich interpretation too costly? Infant Behav. Dev. 21, 167–180 (1998).
Spelke, E. S. Nativism, empiricism and the origins of knowledge. Infant Behav. Dev. 21, 181–200 (1998).
Spelke, E. S. et al. Origins of knowledge. Psychol. Rev. 99, 605–632 (1992).
Munakata, Y. et al. Rethinking infant knowledge: towards an adaptive process account of successes and failures in object permanence tasks. Pyschol. Rev. 104, 686–713 (1997).
Mareschal, D., Plunkett, K. & Harris, P. A computational and neuropsychological account of object-oriented behaviours in infancy. Dev. Sci. 2, 306–317 (1999).
Johnson, S. C. & Aslin, R. N. Perception of object unity in young infants: the roles of motion, depth and orientation. Cogn. Dev. 11, 161–180 (1996).
Slater, A. et al. The role of three-dimensional depth cues in infants' perception of partly occluded objects. Early Dev. Parenting 3, 187–191 (1995).
Xu, F. & Carey, S. Infants' metaphysics: the case of numerical identity. Cogn. Psychol. 30, 111–153 (1996).
Wilcox, T. & Baillargeon, R. Object individuation in infancy: the use of featural information in reasoning about occlusion events. Cogn. Psychol. 37, 97–155 (1998).
Leslie, A. M. et al. Indexing and the object concept: developing 'what' and 'where' systems. Trends Cogn. Sci. 2, 10–18 (1997).
Csibra, G. et al. Gamma oscillations and object processing in the infant brain. Science 290, 1582–1585 (2000).The first demonstration of task-related 'bursts' of neural oscillations in human infants of 8 months. These oscillatory bursts correspond to the ability of the brain to 'bind' spatially separate features into a new single object and provide a direct measure of infants' ability to process objects.
Brothers, L. & Ring, B. A neuroethological framework for the representation of minds. J. Cogn. Neurosci. 4, 107–118 (1992).
Baron-Cohen, S. How to build a baby that can read minds: cognitive mechanisms in mindreading. Curr. Psychol. Cogn. 13, 513–552 (1994).
Duchaine, B., Cosmides, L. & Tooby, J. Evolutionary psychology and the brain. Curr. Opin. Neurobiol. 11, 225–230 (2001).
Johnson, M. H. et al. Newborns' preferential tracking of face-like stimuli and its subsequent decline. Cognition 40, 1–19 (1991).
Valenza, E. et al. Face preference at birth. J. Exp. Psychol. Hum. Percept. Perform. 22, 892–903 (1996).Confirms previous work, but with an improved methodology, showing that newborns will preferentially orient towards simple face-like patterns.
Mondloch, C. J. et al. Face perception during early infancy. Psychol. Sci. 10, 419–422 (1999).
Morton, J. & Johnson, M. H. CONSPEC and CONLERN: a two-process theory of infant face recognition. Psychol. Rev. 98, 164–181 (1991).
Hood, B. M., Willen, J. D. & Driver, J. Adult's eyes trigger shifts of visual attention in human infants. Psychol. Sci. 9, 53–56 (1998).An important link between research on attentional cueing in young babies, and work on social cognition and joint attention. Shows that the attention of young infants can be cued to a target location by the direction of eye gaze of a realistic face.
Farroni, T. et al. Infants' use of gaze direction to cue attention: the importance of perceived motion. Vis. Cogn. 7, 705–718 (2000).
Johnson, S., Slaughter, V. & Carey, S. Whose gaze will infants follow? The elicitation of gaze-following in 12-month-olds. Dev. Sci. 1, 233–238 (1998).
Gergely, G. et al. Taking the intentional stance at 12 months of age. Cognition 56, 165–193 (1995).
Meltzoff, A. N. What infant memory tells us about amnesia: long-term recall and deferred imitation. J. Exp. Child Psychol. 59, 497–515 (1995).A study using the imitation method to show that before 2 years of age, children encode the behaviour of other humans in terms of the intended goals of their actions.
Csibra, G. et al. Goal attribution without agency cues: the perception of 'pure reason' in infancy. Cognition 72, 237–267 (1999).
Atkinson, J. Human visual development over the first six months of life: a review and a hypothesis. Hum. Neurobiol. 3, 61–74 (1984).
Richards, J. E. Cortical indexes of saccade planning in infants. Infancy 2, 123–133 (2001).
Johnson, M. H. Cortical maturation and the development of visual attention in early infancy. J. Cogn. Neurosci. 2, 81–95 (1990).
Hood, B. in Advances in Infancy Research (eds Rovee-Collier, C. & Lipsitt, L.) (Ablex, Norwood, New Jersey, 1995).
Johnson, M. H. The inhibition of automatic saccades in early infancy. Dev. Psychobiol. 28, 163–216 (1995).
Csibra, G., Tucker, L. A. & Johnson, M. H. Differential frontal cortex activation before anticipatory and reactive saccades in infants. Infancy 2, 159–174 (2001).
Gilmore, R. O. & Johnson, M. H. Working memory in infancy: six-month-olds' performance on two versions of the oculomotor delayed response task. J. Exp. Child Psychol. 59, 397–418 (1995).
Piaget, J. The Construction of Reality in the Child (Basic Books, New York, 1954).
Diamond, A. & Goldman-Rakic, P. S. Comparison of human infants and infant rhesus monkeys on Piaget's AB task: evidence for dependence on dorsolateral prefrontal cortex. Exp. Brain Res. 74, 24–40 (1989).
Diamond, A. in The Epigenesis of Mind: Essays on Biology and Cognition (eds Carey, S. & Gelman, R.) 67–110 (Lawrence Erlbaum Ass., Hillsdale, New Jersey, 1991).
Bell, M. A. & Fox, N. A. The relations between frontal brain electrical activity and cognitive development during infancy. Child Dev. 63, 1142–1163 (1992).
Diamond, A. et al. Prefrontal cortex cognitive deficits in children treated early and continuously for PKU. Monogr. Soc. Res. Child Dev. 62, 1–208 (1997).
Matthews, A., Ellis, A. E. & Nelson, C. A. Development of preterm and full-term infant ability on AB, recall memory, transparent barrier detour, and means-end tasks. Child Dev. 67, 2658–2676 (1996).
Johnson, M. H. Functional brain development in infants: elements of an interactive specialization framework. Child Dev. 71, 75–81 (2000).
Friston, K. J. & Price, C. J. Dynamic representations and generative models of brain function. Brain Res. Bull. 54, 275–285 (2001).
Neville, H. J., Mills, D. & Lawson, D. Fractionating language: different neural sub-systems with different sensitive periods. Cereb. Cortex 2, 244–258 (1992).
de Haan, M., Oliver, A. & Johnson, M. H. Electrophysiological correlates of face processing by adults and 6-month-old infants. J. Cogn. Neurosci. 10, 36 (1998).
Filipek, P. A. Neuroimaging in the developmental disorders: the state of the science. J. Child Psychol. Psychiatr. 40, 113–128 (1999).
Filipek, P. A. et al. Morphometric analysis of the brain in develomental language disorders and autism. Ann. Neurol. 32, 475 (1992).
Rumsey, J. M. & Ernst, M. Functional neuroimaging of autistic disorders. Ment. Retard. Dev. Disabil. Res. Rev. 6, 171–179 (2000).
Mills, D. L. et al. Electrophysiological studies of face processing in Williams syndrome. J. Cogn. Neurosci. 12, 47–64 (2000).
Miller, E. K. The prefrontal cortex and cognitive control. Nature Rev. Neurosci. 1, 59–65 (2000).
Rushworth, M. F. et al. Ventral prefrontal cortex is not essential for working memory. J. Neurosci. 17, 4829–4838 (1997).
Shadmehr, R. & Holcomb, H. Neural correlates of motor memory consolidation. Science 277, 821–824 (1997).
Johnson, M. H. et al. Visual attention in infants with perinatal brain damage: evidence of the importance of left anterior lesions. Dev. Sci. 1, 53–58 (1998).
Craft, S. & Schatz, J. The effects of bifrontal stroke during childhood on visual attention: evidence from children with sickle cell anemia. Dev. Neuropsychol. 10, 285–297 (1994).
Gauthier, I. et al. Activation of the middle fusiform 'face area' increases with expertise in recognizing novel objects. Nature Neurosci. 2, 568–573 (1999).
Gauthier, I. & Nelson, C. A. The development of face expertise. Curr. Opin. Neurobiol. 11, 219–224 (2001).
Rossion, B. et al. The N170 occipito-temporal component is delayed and enhanced to inverted faces but not to inverted objects: an electrophysiological account of face-specific processes in the human brain. Neuroreport 11, 69–74 (2000).
Maurer, D. et al. Rapid improvement in the acuity of infants after visual input. Science 286, 108–110 (1999).A study with patients visually deprived over the first months or years of life owing to cataracts. The improvements in acuity following corrective surgery were surprisingly rapid, although some degree of deficit remained even after years of restored vision.
Le Grand, R. et al. Neuroperception: early visual experience and face processing. Nature 410, 890 (2001).
Karmiloff-Smith, A. Development itself is the key to understanding developmental disorders. Trends Cogn. Sci. 2, 389–398 (1998).
Paterson, S. J. et al. Cognitive modularity and genetic disorders. Science 286, 2355–2358 (1999).A study that investigated whether the profiles of cognitive abilities and disabilities observed in adults with developmental disorders are also observed during infancy. The results show that profiles of cognitive disability might change during development.
Kellman, P. and Spelke, E. S. Perception of partly occluded objects in infancy. Cogn. Psychol. 15, 483–524 (1983).
Baillargeon, R., Spelke, E. S. & Wasserman, S. Object permanence in five-month-old infants. Cognition 20, 191–208 (1985).
Sakai, K. et al. Transition of brain activation from frontal to parietal areas in visuo-motor sequence learning. J. Neurosci. 18, 1827–1840 (1998).
I thank D. Maurer, A. Karmiloff-Smith and D. Mareschal for comments on the manuscript. The UK Medical Research Council supports the author's research.
A decrease in the behavioural response to a repeated, benign stimulus.
A rapid eye movement that brings the point of maximal visual acuity — the fovea — to the image of interest.
- BALINT'S SYNDROME
A neurological disorder caused by bilateral damage to the parieto-occipital region of the brain, characterized by disorders of spatial perception.
An inherited inability to metabolize phenylalanine which can result in brain and nerve damage leading to mental retardation.
- WILLIAMS' SYNDROME
A rare congenital disorder: symptoms include facial abnormalities and deficits in some cognitive skills.
A category of computer-generated novel objects, originally designed as a control set for faces. Like faces, Greebles are all similar because they have the same number of parts in the same configuration.
- NEAR INFRARED SPECTROSCOPY
A form of optical (light) imaging that entails placing sources and detectors on the head, and measuring the scatter or bending of light as it passes through the skull and brain.
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