Natural selection and resistance to HIV

A genotype that lowers susceptibility to HIV extends survival at a time of peak fertility.

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Figure 1: Expected lifetime reproduction of carriers of CCR5 mutations relative to the normal CCR5 genotype as a function of the period between HIV infection and the onset of AIDS.

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Correspondence to Paul Schliekelman.

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Schliekelman, P., Garner, C. & Slatkin, M. Natural selection and resistance to HIV. Nature 411, 545–546 (2001). https://doi.org/10.1038/35079176

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