The cellular protein-degrading machinery detects target proteins by the signals they display. One such signal works for artificial test proteins, but only now has a natural equivalent been found.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rao, H., Uhlmann, F., Nasmyth, K. & Varshavsky, A. Nature 410, 955–959 (2001).
Bachmair, A., Finley, D. & Varshavsky, A. Science 234, 179–186 (1986).
Bachmair, A. & Varshavsky, A. Cell 56, 1019–1032 (1989).
Hershko, A., Ciechanover, A. & Varshavsky, A. Nature Med. 6, 1073–1081 (2000).
Bartel, B., Wunning, I. & Varshavsky, A. EMBO J. 9, 3179–3189 (1990).
Kwon, Y. T. et al. Proc. Natl Acad. Sci. USA 95, 7898–7903 (1998).
Varshavsky, A., Turner, G., Du, F. & Xie, Y. Biol. Chem. 381, 779–789 (2000).
de Groot, R. J., Rumenapf, T., Kuhn, R. J., Strauss, E. G. & Strauss, J. H. Proc. Natl Acad. Sci. USA 88, 8967–8971 (1991).
Sijts, A. J., Pilip, I. & Pamer, E. G. J. Biol. Chem. 272, 19261–19268 (1997).
Mulder, L. C. & Muesing, M. A. J. Biol. Chem. 275, 29749–29753 (2000).
Nasmyth, K., Peters, J. M. & Uhlmann, F. Science 288, 1379–1385 (2000).
Uhlmann, F., Wernic, D., Poupart, M. A., Koonin, E. V. & Nasmyth, K. Cell 103, 375–386 (2000).
Waizenegger, I. C., Hauf, S., Meinke, A. & Peters, J. M. Cell 103, 399–410 (2000).
Cohen-Fix, O., Peters, J. M., Kirschner, M. W. & Koshland, D. Genes Dev. 10, 3081–3093 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scheffner, M., Whitaker, N. Proteolytic relay comes to an end. Nature 410, 883–885 (2001). https://doi.org/10.1038/35073728
Issue Date:
DOI: https://doi.org/10.1038/35073728