Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Opinion
  • Published:

Scientific perspectives on regulating the safety of genetically modified foods

Abstract

Regulation is often seen as the dull end of science. The recent storm over the introduction of genetically modified foods and the calls to regulate their consumption have had a negative effect on development of the science. Assuring the safety of genetically modified foods might raise questions where existing scientific data is limited and underline the need for further research.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ewan, S. W. B. & Pusztai, A. Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet 354, 1353– 1354 (1999).

    Article  Google Scholar 

  2. The Royal Society. Review of data on possible toxicity of GM potatoes. http://www.royalsoc.ac.uk/policy/index.html (search 'pusztai') (1999).

  3. GM food safety: facts, uncertainties and assessment . The OECD Edinburgh Conference on the Scientific and Health Aspects of Genetically Modified Foods. Published by OECD as Genetically Modified Foods, Widening the Debate an Health and Safety. (OECD 2000). www.oecd.org/subject/biotech/edinburgh.htm)

  4. Chen, Z.-L. et al. Safety assessment for transgenic sweet pepper and tomato (submitted)

  5. Teshima, R. et al. Effect of GM and non-GM soybeans on the immune system of BN rats and BlOA mice. J. Food Hyg. Soc. Japan 41, 188–193 (2000).

    Article  CAS  Google Scholar 

  6. Nuffield Council on Bioethics in Genetically Modified Crops: the Ethical and Social Issues. 96 –105 (Nuffield Council on Bioethics, London, 1999). Also see http://www.nuffield.org/bioethics/publication/modifiedcrops/index.html

  7. Food and Agriculture Organisation/World Health Organisation Strategies for Assessing the Safety of Foods Produced by Biotechnology (WHO, Geneva, 1991).

  8. Organisation for Economic Cooperation and Development Safety Evaluation of Foods Produced by Modern Biotechnology — Concepts and Principles (OECD, Paris, 1993).

  9. Food and Agriculture Organisation/World Health Organization . Biotechnology and Food Safety (FAO, Rome, 1996).

  10. Millstone, E., Brunner, E. & Mayer, S. Beyond 'substantial equivalence'. Nature 401, 525–526 ( 1999).

    Article  CAS  Google Scholar 

  11. Trewavas, T. & Leaver, C. J. Conventional crops are the test of GM prejudice. Nature 401, 640 (1999).

    Article  CAS  Google Scholar 

  12. Burke, D. C. No GM conspiracy. Nature 401, 640– 641 (1999).

    Article  CAS  Google Scholar 

  13. Kearns, P. & Mayers, P. Substantial equivalence is a useful tool. Nature 401, 640 ( 1999).

    Article  CAS  Google Scholar 

  14. Hammond, J. R. M. Genetically-modified brewing yeasts for the twenty-first century. Progress to date. Yeast 11, 1613– 1627 (1995)

    Article  CAS  Google Scholar 

  15. Advisory Committee on Novel Foods and Processes Annual Report 1993. Ministry of Agriculture, Fisheries and Food/Department of Health, Crown Copyright PB1856 (1994).

  16. Monsanto Company Reports. Molecular Characterisation and Safety Assessment of Roundup Ready Soybean Event 40-3–2 http://www.foodstandards.gov.uk/pdf_files/acnfp/summary.pdf (2000).

  17. Ishida, Y. et al. High efficiency transformation of maize (Zea mays L.) mediated by Agrobacterium tumefaciens. Nature Biotechnol. 14, 745–750 (1996).

    Article  CAS  Google Scholar 

  18. Nap, J. P., Bijovoet, J. & Stiekma, W. J. Biosafety of kanamycin-resistant transgenic plants . Transgenic Res. 1, 239– 249 (1992).

    Article  CAS  Google Scholar 

  19. ACNFP Advisory Committee on Novel Foods and Processes Annual Report 1995. Ministry of Agriculture, Fisheries and Food/Department of Health, Crown Copyright PB3203 (1996).

  20. Pechere, J.-C. α-lactamase gene in a transgenic maize? Antibiotics Chemotherapy 1, 9 (1997).

    Google Scholar 

  21. Pechere, J.-C. Concerns about the presence of α-lactamase gene in transgenic maize? Antibiotics Chemotherapy 2, 16 (1998).

    Google Scholar 

  22. Komari, T., Hiei, Y., Saito, Y., Murai, N. & Kumashiro, T. Vectors carrying two separate T-DNAs for co-transformation of higher plants mediated by Agrobacterium tumefaciens and segregation of the transformants freed from selection marker. Plant J. 10, 165–174 (1996).

    Article  CAS  Google Scholar 

  23. Dale, E. C. & Ow, D. W. Gene transfer with subsequent removal of the selection gene from the host genome. Proc. Natl Acad. Sci. USA 88, 10558–10562 (1991).

    Article  CAS  Google Scholar 

  24. Anon. Novartis pins hopes for GM seeds on new marker system. Nature 406, 924 ( 2000).

  25. Mercer, D. K., Scott, K. P., Bruce-Johnson, W. A., Glover, L. A. & Flint, H. J. Fate of free DNA and transformation of the oral bacterium Streptococcus gordonii DL1 by plasmid DNA in human saliva. Appl. Environ. Microbiol. 65, 6–10 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Chambers, P. A., Duggan, P. S., Heritage, J. & Forbes, J. M. Survival of DNA from feeding stuffs in the gastrointestinal tract of chickens . Nature Biotechnol. (in the press) (2000 ).

  27. Schubbert, R., Lettmann, C. & Doerfler, W. Ingested foreign (PhageM13) survives transiently in the gastrointestinal tract and enters the bloodstream of mice. Mol. Gen. Genet. 242, 495–504 (1994).

    Article  CAS  Google Scholar 

  28. Schubbert, R., Renz, D., Schmitz, B. & Doerfler, W. Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA. Proc. Natl Acad. Sci. USA 94, 961– 966 (1997).

    Article  CAS  Google Scholar 

  29. Schubbert, R., Hohlweg, U., Renz, D. & Doerfler, W. On the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission to the fetus. Mol. Gen. Genet. 259, 569–576 (1998).

    Article  CAS  Google Scholar 

  30. Beever, D. E. & Kemp, C. F. Safety issues associated with the DNA in animal feed derived from genetically modified crops. A review of scientific and regulatory procedures. Nutrition Abstracts and Reviews. Series B: Livestock Feeds and Feeding 70, 175– 182 (2000).

    Google Scholar 

  31. Lorenz, M. G. & Wackernagel, W. Bacterial gene transfer by natural genetic transformation in the environment. Microbiol. Rev. 58, 563–602 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Gasson, M. J. Gene transfer from genetically modified food. Curr. Opin. Biotechnol. 11, 505–508 ( 2000).

    Article  CAS  Google Scholar 

  33. Schluter, K., Futterer, J. & Potrykus, I. 'Horizontal' gene transfer from a transgenic potato line to a bacterial pathogen (Erwinia chysanthemi) occurs — if at all — at an extremely low frequency. Biotechnology 13, 1094–1098 (1995).

    Article  CAS  Google Scholar 

  34. De Vries, J. & Wackernagel, W. Detection of nptII kanamycin resistance genes in genomes of transgenic plants by marker-rescue transformation . Mol. Gen. Genet. 257, 606– 613 (1998).

    Article  CAS  Google Scholar 

  35. Gebhard, F. & Smalla, K. Transformation of Acinetobacter sp. strain BD413 by transgenic sugar beet DNA. Appl. Environ. Microbiol. 64, 1550–1554 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Lean, G., Angres, V. & Jury, L. GM genes 'can spread to people and animals'. The Independent (28 May 2000).

  37. Metcalf, D. B. et al. Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit. Rev. Food Sci. Nutr. 36, S165–S186 ( 1996)

    Article  Google Scholar 

  38. Protall. Food allergens of plant origin — the relationship between allergenic potential and biological activity www.ifr.bbsrc.ac.uk/protall. Published by the Institute for Food Research, August 2000.

  39. Open letter from Professor S. L. Taylor, (22 September 2000). http://www.who.int/fsf/Gmfood/Consultation_May2000/Biotech_00_07 (2000).

  40. Dale, P. J. Public reactions and scientific responses to transgenic crops. Curr. Opin. Biotechnol. 10, 203–208 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Derek Burke.

Related links

Related links

FURTHER INFORMATION

Substantial equivalence

Royal Society critique of Pusztai's experiments

Facts on GMOs in the European Union

OECD

WHO

FAO

Glossary

CALF CHYMOSIN

Active ingredient of rennet, used to clot milk during cheese manufacture. It is a proteolytic enzyme that breaks the milk protein k-casein, thereby effecting a change in texture.

CRE/LOX

A site-specific recombination system derived from Escherichia coli bacteriophage P1. Two short DNA sequences (lox sites) are engineered to flank the target DNA. Activation of the Cre-recombinase enzyme catalyses recombination between the lox sites, leading to excision of the intervening sequence.

RHIZOSPHERE

The region in the soil surrounding the root system of a plant, affected by the excretions from the roots and characterized by considerable microbiological activity.

SUPERWEEDS

Plants with a genetic predisposition to aggressive weediness. This can be induced unintentionally by genetic modification.

TERMINATOR TECHNOLOGY

Genetic modification intended to prevent a GM plant cultivar from setting seed.

WEEDINESS

Tendency of a plant to grow where it is not wanted by humans.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gasson, M., Burke, D. Scientific perspectives on regulating the safety of genetically modified foods. Nat Rev Genet 2, 217–222 (2001). https://doi.org/10.1038/35056066

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35056066

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing