Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Vascular biology

Targeted delivery of nitric oxide

Nitric oxide is a biological signalling gas that has been assumed to reach its protein targets by simple random diffusion. The discovery of molecular mechanisms for precise nitric oxide delivery challenges that assumption.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A model for how red blood cells sequentially consume and release nitric oxide (NO) for control of blood flow.

References

  1. Pawloski, J. R., Hess, D. T. & Stamler, J. S. Nature 409, 622–626 (2001).

    Article  ADS  CAS  Google Scholar 

  2. Liao, J. C. et al. Proc. Natl Acad. Sci. USA 96, 8757–8761 (1999).

    Article  ADS  CAS  Google Scholar 

  3. Liu, X. et al. J. Biol. Chem. 273, 18709–18713 (1998).

    Article  CAS  Google Scholar 

  4. Vaughn, M. W. et al. J. Biol. Chem. 275, 2342–2348 (2000).

    Article  CAS  Google Scholar 

  5. Jia, L. et al. Nature 380, 221–226 (1996).

    Article  ADS  CAS  Google Scholar 

  6. Gow, A. J. & Stamler, J. S. Nature 391, 169–173 (1998).

    Article  ADS  CAS  Google Scholar 

  7. Gross, S. S. & Lane, P. Proc. Natl Acad. Sci. USA 96, 9967–9969 (1999).

    Article  ADS  CAS  Google Scholar 

  8. Walder, J. A. et al. J. Biol. Chem. 259, 10238–10246 (1984).

    CAS  PubMed  Google Scholar 

  9. Stamler, J. S. et al. Neuron 18, 691–696 (1997).

    Article  CAS  Google Scholar 

  10. Fang, M. et al. Neuron 28, 183–193 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steven S. Gross.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gross, S. Targeted delivery of nitric oxide. Nature 409, 577–578 (2001). https://doi.org/10.1038/35054661

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35054661

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing