The molecular mechanisms underlying the link between obesity and diabetes have been elusive. A new protein, christened 'resistin', can now be added to the panoply of factors that may be involved.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
HMGB2 orchestrates mitotic clonal expansion by binding to the promoter of C/EBPβ to facilitate adipogenesis
Cell Death & Disease Open Access 02 July 2021
-
Clinical implication of changes in serum adiponectin in patients with hepatogenic diabetes
Scientific Reports Open Access 03 July 2014
-
Rapid increases in obesity in Jamaica, compared to Nigeria and the United States
BMC Public Health Open Access 23 April 2008
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Steppan, C. M. et al. Nature 409, 307–312 (2001).
Kahn, B. B. & Flier, J. S. J. Clin. Invest. 106 , 473–481 (2000).
Boden, G. Proc. Assoc. Am. Physicians 111, 241– 248 (1999).
Hotamisligil, G. S., Peraldi, P. & Spiegelman, B. M. Curr. Opin. Endocrinol. Diab. 3, 16–23 (1996).
Friedman, J. M. & Halaas, J. L. Nature 395, 763–770 (1998).
Ahima, R. S. & Flier, J. S. Annu. Rev. Physiol. 62, 413–437 (2000).
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S. & Goldstein, J. L. Nature 401, 73–76 (1999).
Considine, R. V. et al. New Engl. J. Med. 334, 292– 295 (1995).
Olefsky, J. M. J. Clin. Invest. 106, 467–472 (2000).
Lehmann, J. M. et al. J. Biol. Chem. 270, 12953– 12956 (1995).
Tontonoz, P. et al. Genes Dev. 8, 1224– 1234 (1994).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Flier, J. The missing link with obesity?. Nature 409, 292–293 (2001). https://doi.org/10.1038/35053251
Issue Date:
DOI: https://doi.org/10.1038/35053251
This article is cited by
-
HMGB2 orchestrates mitotic clonal expansion by binding to the promoter of C/EBPβ to facilitate adipogenesis
Cell Death & Disease (2021)
-
Clinical implication of changes in serum adiponectin in patients with hepatogenic diabetes
Scientific Reports (2014)
-
B Cell‐Activating Factor Controls the Production of Adipokines and Induces Insulin Resistance
Obesity (2011)
-
Rapid increases in obesity in Jamaica, compared to Nigeria and the United States
BMC Public Health (2008)
-
Increased serum resistin in elite endurance athletes with high insulin sensitivity
Diabetologia (2006)