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RNA splicing

The case for an RNA enzyme

New evidence suggests that RNA splicing, the removal of non-coding parts of a messenger RNA, is catalysed by an RNA component of the splicing machinery. This component binds a crucial metal ion.

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Figure 1: Is the spliceosome an RNA-based enzyme?

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Correspondence to Timothy W. Nilsen.

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Nilsen, T. The case for an RNA enzyme. Nature 408, 782–783 (2000). https://doi.org/10.1038/35048655

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