Oligonucleotide analogues offer several mechanisms for potential therapeutic action; triple helix agents that inhibit disease-causing genes at the DNA level show particular promise.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ellington, A.D. & Szostak, J. Nature 346, 818–822 (1990).
Izant, J.G. & Weintraub, H. Cell 36 1007–1015 (1984).
Melton, D.A. Proc. natn. Acad. Sci. U.S.A. 82, 144–148 (1985).
Uhlmann, E. & Peyman, A. Chem. Rev. 90, 543–584 (1990).
Shaw, J.P., Kent, K., Bird, J., Fishback, J. & Froehler, Nucleic Acids Res. 19, 747–750 (1991).
Matteucci, M. Tetrahedron Lett. 31 2385–2388 (1990).
Moser, H.E. & Dervan, P.B. Science 238 645–650 (1987).
Povsic, T.J. & Dervan, P.B. J. Am. chem. Soc. 112, 9428–9430 (1990).
McCurdy, S., Moulds, C. & Froehler, B. Nucleosides Nucleotides (in the press).
Horne, D.A. & Dervan, P.B. J. Am. chem. Soc. 112, 2435–2437 (1990).
Maher, L.J., Wold, B. & Dervan, P.B. Science 245, 725–730 (1989).
Tuerk, C. & Gold, L. Science 249, 505–510 (1990).
Blackwell, T.K. & Weintraub, H. Science 250, 1104–1110 (1990).
Blackwell, T.K., Kretaner, L., Blackwood, E.M., Eisenman, R.N. & Weintraub, H. Science 250, 1149–1151 (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Riordan, M., Martin, J. Oligonucleotide-based therapeutics. Nature 350, 442–443 (1991). https://doi.org/10.1038/350442a0
Issue Date:
DOI: https://doi.org/10.1038/350442a0
This article is cited by
-
Spectroscopic Study on the Effect of Imidazophenazine Tethered to 5′-End of Pentadecathymidilate on Stability of Poly(dA)·(dT)15 Duplex
Journal of Fluorescence (2012)
-
Large-scale oligonucleotide synthesizers
Applied Biochemistry and Biotechnology (1995)
-
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures
Nature (1992)
-
Solid-phase gene assembly
Nature (1991)