Krebs and his trinity of cycles

Nature Reviews Molecular Cell Biology volume 1, pages225–228(2000)Cite this article

Abstract

Everyone who has ever taken biology at school has heard of the Krebs cycle, but few realize that Hans Krebs also discovered two other cycles. It is appropriate, at the centenary of his birth, to consider the circumstances and experiments that led Krebs to establish these metabolic pathways.

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Figure 1: Sir Hans Krebs on a motorized cycle.
Figure 2: The ornithine cycle.
Figure 3
Figure 4: The tricarboxylic acid (TCA) and glyoxylate cycles, formulated by Kornberg and Krebs20 in 1957.

References

  1. 1

    Kossel, A. & Dakin, H. D. Über die Arginase. Z. Physiol. Chem. 41, 321–331 (1904).

    Article  Google Scholar 

  2. 2

    Wada, M. Über Citrullin, eine neue Aminosaure im presssaft der Wassermelone, Citrullis vulgaris schrad. Biochem. Z. 224, 420 –429 (1930).

    CAS  Google Scholar 

  3. 3

    Ackermann, D. Über den biologischen Abbau des Arginins zu Citrullin. Biochem. Z. 203, 66–69 ( 1931).

    CAS  Google Scholar 

  4. 4

    Krebs, H. A. & Henseleit, K. Untersuchungen über die Harnstoffbildung im tierkorper. Z. Physiol. Chem. 210, 33 –66 (1932).

    CAS  Article  Google Scholar 

  5. 5

    Annau, E. et al. Über die Bedeutung der Fumarsaure fur die tierische Gewabsatmung . Z. Physiol. Chem. 235, 1– 68 (1935).

    Article  Google Scholar 

  6. 6

    Krebs, H. A. & Johnson, W. A. Metabolism of ketonic acids in animal tissues. Biochem. J. 31, 645– 660 (1937).

    CAS  Article  Google Scholar 

  7. 7

    Martius, C. & Knoop, F. Der physiologische Abbau der Citronensaure. Vorläufige mitteilung. Z. Physiol. Chem. 246, 1–11 (1936).

    Google Scholar 

  8. 8

    Martius, C. Über den Abbau der Citronensaure. Z. Physiol. Chem. 247, 104–110 (1937).

    CAS  Article  Google Scholar 

  9. 9

    Krebs, H. A. & Johnson, W. A. The role of citric acid in intermediate metabolism in animal tissues. Enzymologia 4, 148–156 (1937).

    CAS  Google Scholar 

  10. 10

    Quastel, J. H. & Whetham, M. D. The equilibria existing between succinic, fumaric and malic acids in the presence of resting bacteria. Biochem. J. 18, 519– 534 (1924).

    CAS  Article  Google Scholar 

  11. 11

    Quastel, J. H. & Whetham, M. D. Dehydrogenations produced by resting bacteria. Biochem. J. 19, 520–531 (1925).

    CAS  Article  Google Scholar 

  12. 12

    Stern, J. R. & Ochoa, S. Enzymatic synthesis of citric acid by condensation of acetate and oxaloacetate. J. Biol. Chem. 179, 491–492 (1949).

    CAS  PubMed  Google Scholar 

  13. 13

    Stern, J. R. et al. Enzymatic synthesis of citric acid. V. Reaction of acetyl coenzyme A. J. Biol. Chem. 198, 313– 321 (1952).

    CAS  PubMed  Google Scholar 

  14. 14

    Bassham, J. A. & Calvin, M. The Path of Carbon in Photosynthesis (Prentice–Hall, Englewood Cliffs, New Jersey, 1957).

    Google Scholar 

  15. 15

    Kornberg, H. L. The metabolism of C2-compounds in micro-organisms. 1. The incorporation of [2-14C]-acetate by Pseudomonas fluorescens, and by a Corynebacterium, grown on ammonium acetate. Biochem. J. 68, 535–542 (1958).

    CAS  Article  Google Scholar 

  16. 16

    Kornberg, H. L. & Quayle, J. R. The metabolism of C2-compounds in micro-organisms. 2. The effect of carbon dioxide in the incorporation of [14C]-acetate by acetate-grown Pseudomonas KB 1. Biochem. J. 68, 542 –549 (1958).

    CAS  Article  Google Scholar 

  17. 17

    Kornberg, H. L. & Madsen, N. B. Synthesis of C4-dicarboxylic acids from acetate by a glyoxylate bypass of the tricarboxylic acid cycle. Biochim. Biophys. Acta 24 , 651–653 (1957).

    CAS  Article  Google Scholar 

  18. 18

    Wong, D. T. O. & Ajl, S. J. Conversion of acetate and glyoxylate to malate. J. Am. Chem. Soc. 78, 3230–3231 (1956).

    CAS  Article  Google Scholar 

  19. 19

    Smith, R. A. & Gunsalus, I. C. Isocitratase: A new tricarboxylic acid cleavage system. J. Am. Chem. Soc. 76, 5002–5003 (1954).

    CAS  Article  Google Scholar 

  20. 20

    Kornberg, H. L. & Krebs, H. A. Synthesis of cell constituents from C2-units by a modified tricarboxylic acid cycle. Nature 179, 988– 991 (1957).

    CAS  Article  Google Scholar 

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Affiliations

  1. the Department of Biology, Boston University, 2 Cummington Street, Boston, 02215, Massachusetts, USA

    Hans Kornberg

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  1. Hans Kornberg
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Krebs, Hans Adolf

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Kornberg, H. Krebs and his trinity of cycles. Nat Rev Mol Cell Biol 1, 225–228 (2000). https://doi.org/10.1038/35043073

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