For 50 years now, one of the enigmas of molecular evolution has been the C-value paradox, which refers to the often massive, counterintuitive and seemingly arbitrary differences in genome size observed among eukaryotic organisms. For example, the genome of the fruitfly Drosophila melanogaster is 180 megabases (Mb), whereas that of the European brown grasshopper Podisma pedestris is 18,000 Mb. The difference in genome size of a factor of 100 is difficult to explain in view of the apparently similar levels of evolutionary, developmental and behavioural complexity of these organisms.
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Acknowledgements
I am very grateful to my colleagues D. Petrov and E. Lozovskaya for their contributions to the work described here, and to D. Petrov for having allowed me to read an early draft of a manuscript of his own. This work was supported by a grant from the National Institutes of Health.
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Glossary
- GENETIC DRIFT
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Random changes in allele frequency that result because the genes appearing in offspring are not a perfectly representative sampling of the parental genes (e.g. in small populations).
- PSEUDOGENE
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A DNA sequence originally derived from a functional protein-coding gene that has lost its function owing to the presence of one or more inactivating mutations.
- ORTHOLOGOUS GENES
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Homologous genes in different species whose lineages derive from a common ancestral gene without gene duplication or horizontal transmission.
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Hartl, D. Molecular melodies in high and low C. Nat Rev Genet 1, 145–149 (2000). https://doi.org/10.1038/35038580
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DOI: https://doi.org/10.1038/35038580
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