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Perspectives for vascular genomics

Nature volume 407, pages 265–269 (2000)Cite this article

Abstract

Diseases of the vascular system result from a complex mixture of genetic and environmental factors. Data sets, technologies and strategies emanating from the human genome programme have been applied to the analysis of both rare single-gene and common multigenic vascular disorders. Genomic approaches including inter- and intraspecies sequence comparisons, genotyping with dense marker sets spanning the genome, large-scale mutagenesis screens of model organisms, and genome-wide expression profiling have all begun to contribute to the identification of new genes and mechanisms that are central to cardiovascular disease processes.

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Figure 1: Comparative sequences of human and mouse DNA.
Figure 2: Identification of SNPs.
Figure 3: Genome-wide mutagenesis.
Figure 4: Expression array profiling.

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Authors and Affiliations

  1. Division of Molecular Medicine, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, 10032, New York, USA

    Edward M. Rubin & Alan Tall

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  1. Edward M. Rubin
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  2. Alan Tall
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Correspondence to Edward M. Rubin.

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Rubin, E., Tall, A. Perspectives for vascular genomics. Nature 407, 265–269 (2000). https://doi.org/10.1038/35025236

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