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Thrombin signalling and protease-activated receptors

Nature volume 407, pages 258264 (14 September 2000) | Download Citation

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Abstract

How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

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Acknowledgements

I thank B. Black, H. Bourne, I. Charo, P.-T. Chuang, C. Esmon and the members of my laboratory for critical reading of the manuscript, and T. Schoop for illustrations.

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Correspondence to Shaun R. Coughlin.

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https://doi.org/10.1038/35025229

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