Vascular-specific growth factors and blood vessel formation


A recent explosion in newly discovered vascular growth factors has coincided with exploitation of powerful new genetic approaches for studying vascular development. An emerging rule is that all of these factors must be used in perfect harmony to form functional vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.

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Figure 1: Schematic representation of three families of vascular growth factors and their receptor interactions.
Figure 2: Schematic representation of the roles of VEGF, Ang1, Ang2 and ephrin-B2 during vessel formation.
Figure 3: Models of tumour angiogenesis.


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Yancopoulos, G., Davis, S., Gale, N. et al. Vascular-specific growth factors and blood vessel formation. Nature 407, 242–248 (2000).

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