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reply: Investigating T-cell memory

Nature volume 407, page 40 (07 September 2000) | Download Citation



Maris et al. reply — Mantovani suggests that expression of human placental alkaline phosphatase in activated T cells might stimulate an immune response against PLAP and that the anti-PLAP antibodies generated could lead to the elimination of CD8+ T cells expressing large amounts of PLAP on their surface. We therefore tested whether doubly transgenic (GranzymeB–Cre × CD2–STOP–PLAP) mice could mount an antibody response against PLAP during the course of a response against LCMV, and whether the serum of these mice contained antibodies against human PLAP.

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Author information


  1. *Emory University, Atlanta , Georgia 30322, USA

    • Charles H. Maris
    •  & Joshy Jacob
  2. †California Institute of Technology , Pasadena, California 91125, USA

    • David Baltimore


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