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Investigating T-cell memory

Nature volume 407, page 40 (07 September 2000) | Download Citation



Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore1 have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results1,2. I suggest that the particular enzyme (human placental alkaline phosphatase) chosen for irreversible marking in postnatal life contributes to certain features of this system and perturbs the homeostatic mechanisms of T-cell activation and death.

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    & Nature 399 593–597 (1999).

  2. 2.

    Nature 399 531–532 ( 1999).

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    & Crit. Rev. Clin. Lab. Sci. 32 1–39 (1995).

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    & Proc. Natl Acad. Sci. USA 84 7051–7055 (1987).

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Correspondence to Alberto Mantovani.

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