Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus

Article metrics

Abstract

Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V β elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V β14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Kappler, J. W., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).

  2. 2

    Kappler, J. W. et al. Cell 49, 263–271 (1987).

  3. 3

    Kappler, J. W., Staerz, U., White, J. & Marrack, P. C. Nature 332, 35–40 (1988).

  4. 4

    MacDonald, H. R. et al. Nature 332, 40–45 (1988).

  5. 5

    Kisielow, P., Blüthmann, H., Staerz, U. D., Steinmetz, M. & von Boehmer, H. Nature 333, 742–746 (1988).

  6. 6

    Kisielow, P., Teh, H. S., Blüthmann, H. & von Boehmer, H. Nature 335, 730–733 (1988).

  7. 7

    Sha, W. C. et al. Nature 336, 73–76 (1988).

  8. 8

    MacDonald, H. R., Lees, R. K., Schneider, R., Zinkernagel, R. M. & Hengartner, H. Nature 336, 471–473 (1988).

  9. 9

    Festenstein, H. Transplant. Rev. 15, 62–88 (1973).

  10. 10

    Abe, R., Foo-Phillips, M. & Hodes, R. J. J. exp. Med. 170, 1059–1073 (1989).

  11. 11

    Bill, J., Kanagawa, O., Woodland, D. L. & Palmer, E. J. exp. Med. 169, 1405–1419 (1989).

  12. 12

    Pullen, A. M., Marrack, P. & Kappler, J. W. Nature 335, 796–801 (1988).

  13. 13

    Pullen, A. M., Marrack, P. & Kappler, J. W. J. Immun. 142, 3033–3037 (1989).

  14. 14

    Berumen, L., Halle-Pannenko, O. & Festenstein, H. Eur. J. Immun. 13, 292–300 (1983).

  15. 15

    Molina, I. J., Cannon, N. A., Hyman, R. & Huber, B. J. Immun. 143, 39–44 (1989).

  16. 16

    Webb, S., Okamoto, A., Ron, Y. & Sprent, J. J. exp. Med. 169, 1–12 (1989).

  17. 17

    Singer, P. A., Balderas, R. S. & Theofilopoulos, A. N. EMBO J. 9, 3641–3648 (1990).

  18. 18

    Vacchio, M. S., Ryan, J. J. & Hodes, R. J. J. exp. Med. 172, 807–813 (1990).

  19. 19

    Fleischer, B. & Schrezenmeier, H. J. exp. Med. 167, 1697–1707 (1988).

  20. 20

    White, J. et al. Cell 56, 27–35 (1989).

  21. 21

    Marrack, P. & Kappler, J. Science 248, 705–711 (1990).

  22. 22

    Woodland, D., Happ, M. P., Bill, J. & Palmer, E. Science 247, 964–967 (1990).

  23. 23

    Kozak, C. et al. J. Virol. 61, 1651–1654 (1987).

  24. 24

    Eicher, E. M. & Lee, B. K. Genetics 125, 431–446 (1990).

  25. 25

    Lee, B. K. & Eicher, E. M. J. Virol. 64, 4568–4572 (1990).

  26. 26

    Buetti, E. & Diggelmann, H. Cell 23, 335–345 (1981).

  27. 27

    Michalides, R., van Nie, R., Hynes, N. & Groner, B. Cell 23, 165–173 (1981).

  28. 28

    Liao, N.-S., Maltzman, K. & Raulet, D. H. J. exp. Med. 170, 135–143 (1990).

  29. 29

    Nusse, R. & Varmus, H. E. Cell 31, 99–109 (1982).

  30. 30

    Peters, G., Brookes, S., Smith, R. & Dickson, C. Cell 33, 369–377 (1983).

  31. 31

    Schneider, R. et al. J. exp. Med. 169, 2149–2158 (1989).

  32. 32

    MacDonald, H. R., Lees, R. K. & Louis, J. A. Prog. Immun. 7, 561–565 (1989).

  33. 33

    Van Klaveren, P., & Bentvelzen, P. J. Virol. 62, 4410–4413 (1988).

  34. 34

    Salmons, B., Erfle, V., Brem, G. & Günzburg, W. H. J. Virol. 64, 6355–6359 (1990).

  35. 35

    Marrack, P., Kushnir, E. & Kappler, J. Nature 349, 524–526 (1991).

  36. 36

    Fasel, N., Pearson, K., Buetti, E. & Diggelmann, H. EMBO J. 1, 3–7 (1982).

  37. 37

    Wellinger, R. J., Garcia, M., Vessaz, A. & Diggelmann, H. J. Virol. 60, 1–11 (1986)

  38. 38

    Kuo, W.-L., Vilander, L. R., Huang, M. & Peterson, D. O. J. Virol. 62, 2394–2402 (1988).

  39. 39

    Moore, R., Dixon, M., Smith, R., Peters, G. & Dickson, C. J. Virol. 61, 480–490 (1987).

  40. 40

    Majors, J. E. & Varmus, H. E. J. Virol. 47, 495–504 (1983).

  41. 41

    Tsubura, A. et al. Cancer Res. 48, 6555–6559 (1988).

  42. 42

    Frankel, W. N., Rudy, C., Coffin, J. M. & Huber, B. T. Nature 349, 526–528 (1991).

  43. 43

    Woodland, D. L., Happ, M. P., Gollub, K. J. & Palmer, E. Nature 349, 529–530 (1991).

  44. 44

    Dyson, P. J., Knight, A. M., Fairchild, S., Simpson, E. & Tomonari, K. Nature 349, 531–532 (1991).

  45. 45

    Speiser, D. E., Schneider, R., Hengartner, H., MacDonald, H. R. & Zinkernagel, R. M. J. exp. Med. 170, 595–600 (1989).

  46. 46

    Rammensee, H.-G., Kroschewsky, R. & Frangoulis, B. Nature 339, 541–544 (1989).

  47. 47

    Webb, S., Morris, C. & Sprent, J. Cell 63, 1249–1256 (1990).

  48. 48

    Blöchlinger, K. thesis, Univ. Lausanne (1986).

  49. 49

    Melton, D. A. et al. Nucleic Acids Res. 12, 7035–7056 (1984).

  50. 50

    Haskins, K. et al. J. exp. Med. 160, 452–471 (1984).

  51. 51

    Behlke, M. A., Chou, H. S., Huppi, K. & Loh, D. Y. Proc. natn. Acad. Sci. U.S.A. 83, 767–771 (1986).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Acha-Orbea, H., Shakhov, A., Scarpellino, L. et al. Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus. Nature 350, 207–211 (1991) doi:10.1038/350207a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.