Abstract
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V β elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V β14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
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Acha-Orbea, H., Shakhov, A., Scarpellino, L. et al. Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus. Nature 350, 207–211 (1991). https://doi.org/10.1038/350207a0
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DOI: https://doi.org/10.1038/350207a0
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