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Bacterial genomics

Treasure trove for cholera research

Nature volume 406, pages 469–470 (2000)Cite this article

The study of this disease has a remarkable history, having spawned central tenets in the fields of epidemiology (starting with John Snow's famous tracing of an outbreak to a water pump in Broad Street, London, in 1854), treatment for diarrhoeal disease, microbial ecology and pathogenesis, and mucosal immunology. The complete genome sequence of a representative isolate from the ongoing seventh pandemic of cholera is described by Heidelberg et al.2 on page 477of this issue, and promises to usher in an exciting era of post-genomic investigation of this organism.

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Figure 1: Vibrio cholerae, the bacterium that causes cholera.

EYE OF SCIENCE/SPL

Figure 2: Distribution on the two Vibrio cholerae chromosomes of key genetic loci required for virulence2.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and the Department of Medicine, Tufts New England Medical Center, NEMC #041, 750 Washington Street, Boston, 02111, Massachusetts, USA

    Matthew K. Waldor

  2. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, 02111, Massachusetts, USA

    Debabrata RayChaudhuri

Authors
  1. Matthew K. Waldor
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  2. Debabrata RayChaudhuri
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Correspondence to Matthew K. Waldor or Debabrata RayChaudhuri.

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Waldor, M., RayChaudhuri, D. Treasure trove for cholera research . Nature 406, 469–470 (2000). https://doi.org/10.1038/35020178

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