Mosaic evolution of brain structure in mammals

Abstract

The mammalian brain comprises a number of functionally distinct systems. It might therefore be expected that natural selection on particular behavioural capacities would have caused size changes selectively, in the systems mediating those capacities1,2,3. It has been claimed, however, that developmental constraints limited such mosaic evolution, causing co-ordinated size change among individual brain components3. Here we analyse comparative data to demonstrate that mosaic change has been an important factor in brain structure evolution. First, the neocortex shows about a fivefold difference in volume between primates and insectivores even after accounting for its scaling relationship with the rest of the brain. Second, brain structures with major anatomical and functional links evolved together independently of evolutionary change in other structures. This is true at the level of both basic brain subdivisions and more fine-grained functional systems. Hence, brain evolution in these groups involved complex relationships among individual brain components.

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Figure 1: Taxonomic differences in relative neocortex size among primates (strepsirhines and haplorhines) and insectivores.
Figure 2: Proportion of brain volume composed of neocortical grey matter in relation to overall brain volume.
Figure 3: Correlated evolution among major brain structures.
Figure 4: Correlated volumetric evolution of functionally related brain structures.

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Acknowledgements

We thank R. Grenyer for permission to use an unpublished phylogeny of insectivores.

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Correspondence to Robert A. Barton.

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Barton, R., Harvey, P. Mosaic evolution of brain structure in mammals. Nature 405, 1055–1058 (2000). https://doi.org/10.1038/35016580

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