Brief Communication | Published:

Delaying the onset of Huntington's in mice

Nature volume 404, pages 721722 (13 April 2000) | Download Citation

Subjects

Abstract

Huntington's disease is an inherited (autosomal dominant) disorder in which there is progressive neurodegeneration, affecting the corpus striatum and cerebral cortex of the brain, and for which there is no known cure. Transgenic mice have been created1,2 that develop a neurodegenerative syndrome that closely models the human disease. Here we show that exposure of these mice to a stimulating, enriched environment from an early age helps to prevent the loss of cerebral volume and delays the onset of motor disorders.

This unremitting disease develops later in animals stimulated by their environment.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Huntington's Disease Collaborative Research Group Cell 72, 971–983 ( 1993).

  2. 2.

    et al. Cell 87, 493–506 (1996).

  3. 3.

    et al. Cell 90, 537–548 (1997).

  4. 4.

    , & Neurobiol. Learn. Mem. 63, 217–219 (1995).

  5. 5.

    , , & Neurobiol. Learn. Mem. 66, 93–96 (1996).

  6. 6.

    , & Neurology 51, 1576– 1583 (1998).

  7. 7.

    et al. J. Neurosci. (in the press).

  8. 8.

    et al. Neuron 23, 181–192 (1999).

  9. 9.

    , & Brain Res. 736, 243– 250 (1996).

  10. 10.

    , , , & Nature Med. 5, 448– 453 (1999).

  11. 11.

    et al. Mov. Disord. 14, 320– 325 (1999).

Download references

Author information

Affiliations

  1. *University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK

    • Anton van Dellen
    • , Colin Blakemore
    •  & Anthony J. Hannan
  2. †Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK

    • Robert Deacon
  3. ‡Department of Virology, University of Natal Medical School, Durban, South Africa

    • Denis York

Authors

  1. Search for Anton van Dellen in:

  2. Search for Colin Blakemore in:

  3. Search for Robert Deacon in:

  4. Search for Denis York in:

  5. Search for Anthony J. Hannan in:

Corresponding author

Correspondence to Anton van Dellen.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/35008142

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.