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Sequence and expression of a metabotropic glutamate receptor

Nature volume 349, pages 760–765 (1991)Cite this article

Abstract

The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2−3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

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Author notes

  1. Shigetada Nakanishi: To whom correspondence should be addressed.

Authors and Affiliations

  1. Institute for Immunology, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Masayuki Masu, Yasuto Tanabe & Kunihiro Tsuchida

  2. Department of Morphological Brain Science, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Ryuichi Shigemoto

Authors
  1. Masayuki Masu
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  2. Yasuto Tanabe
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  3. Kunihiro Tsuchida
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  4. Ryuichi Shigemoto
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  5. Shigetada Nakanishi
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Masu, M., Tanabe, Y., Tsuchida, K. et al. Sequence and expression of a metabotropic glutamate receptor. Nature 349, 760–765 (1991). https://doi.org/10.1038/349760a0

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