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A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

Nature volume 348, pages 744–747 (1990)Cite this article

Abstract

MAJOR histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules4–6. This mechanism is impaired as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II region by deletion mapping in mutants and chromosome-walking. PSF is homologous to mammalian and bacterial ATP-dependent transport proteins, suggesting that it operates in the intracellular transport of peptides.

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Authors and Affiliations

  1. Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Thomas Spies, Maureen Bresnahan, Seiamak Bahrain & Daniele Arnold

  2. Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida, 33612, USA

    George Blanck

  3. Department of Pediatrics, University of Washington, Seattle, Washington, 98195, USA

    Elizabeth Mellins & Donald Pious

  4. Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin, 53706, USA

    Robert DeMars

Authors
  1. Thomas Spies
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  2. Maureen Bresnahan
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  3. Seiamak Bahrain
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  4. Daniele Arnold
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  5. George Blanck
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  6. Elizabeth Mellins
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  7. Donald Pious
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  8. Robert DeMars
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Spies, T., Bresnahan, M., Bahrain, S. et al. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. Nature 348, 744–747 (1990). https://doi.org/10.1038/348744a0

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