Abstract
NERVE growth factor plays an important part in neuron–target interactions in the late embryonic and adult brain. We now report that this growth factor controls the proliferation of neuronal precursors in a defined culture system of cells derived from the early embryonic brain. Neuronal precursor cells were identified by expression of the intermediate filament protein nestin. These cells proliferate in response to nerve growth factor but only after they have been exposed to basic fibroblast growth factor. On withdrawal of nerve growth factor, the proliferative cells differentiate into neurons. Thus, in combination with other growth factors, nerve growth factor regulates the proliferation and terminal differentiation of neuroepithelial stem cells.
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References
Holt, C. E., Bertsch, T. W., Ellis, H. M. & Harris, W. A. Neuron 1, 15–26 (1988).
Luskin, M. B., Pearlman, A. L. & Sanes, J. R. Neuron 1, 635–647 (1988).
Price, J. & Thurlow, L. Development 104, 473–482 (1988).
Ready, D. F., Hansen, T. E. & Benzer, S. Devl Biol. 53, 217–240 (1975).
Turner, D. L. & Cepko, C. L. Nature 238, 131–136 (1987).
Walsh, C. & Cepko, C. Science 241, 1342–1345 (1988).
Wetts, R. & Fraser, S. E. Science 239, 1142–1145 (1988).
Rubin, G. M. Cell 57, 519–520 (1989).
Zipursky, S. L. Trends Neurosci. 12, 183–188 (1989).
McKay, R. D. G. Cell 58, 815–821 (1989).
Bayer, S. A. Int. J. dev. Neurosci. 2, 163–175 (1984).
Frederiksen, K. & McKay, R. D. G. J. Neurosci. 8, 1444–1151 (1988).
Lendahl, U., Zimmerman, L. & McKay R. D. G. Cell 60, 585–595 (1990).
Weiss, S. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2238–2242 (1986).
Gage, F. H., et al. Neuron 2, 1177–1184 (1989).
Birren, S. J. & Anderson, D. J. Neuron 4, 189–201 (1990).
Price, J., Turner, D., Cepko, C. Proc. natn. Acad. Sci. U.S.A. 84, 156–160 (1987).
Purves, D. Body and Brain: A Trophic Theory of Neural Connections (Harvard University Press, Cambridge, Massachusetts, 1988).
Hefti, F. & Hartikka, J. J. Neurosci. 8, 2967–2985 (1988).
Martinez, H., Dreyfus, C., Jonakait, M. & Black, I. Proc. natn. Acad. Sci. U.S.A. 82, 7777–7781 (1985).
Kromer, L. F. Science 235, 214–216 (1986).
Williams, L. R. et al. Proc. natn. Acad. Sci. U.S.A. 83, 9231–9235 (1986).
Hefti, F., Dravid, A. & Hartikka, J. Brain Res. 293, 305–311 (1984).
Hefti, F. J. Neurosci. 6, 2155–2162 (1986).
Maisonpierre P. C., et al. Neuron (in press).
Liebrock, J., et al. Nature 341, 149–152 (1989).
Maisonpierre, P., et al. Science 247, 1446–1451 (1990).
Hohn, A., Lieḃrock, J., Bailey, K. & Barde, Y.-A. Nature 344, 339–341 (1990).
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Cattaneo, E., McKay, R. Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor. Nature 347, 762–765 (1990). https://doi.org/10.1038/347762a0
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DOI: https://doi.org/10.1038/347762a0
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