Abstract
THE segmented pattern of the Drosophila embryo depends on a regulatory cascade involving three main classes of genes1. An early regulatory programme, set up before cellularization, involves direct transcriptional regulation mediated by gap and pair-rule genes. In a second phase occurring after cellularization, interactions between segment-polarity genes are involved in cell communication2,3. Segment-polarity genes are required for pattern formation in different domains of each metamere and act to define and maintain positional information in each segment4. The segment-polarity gene fused is maternally required for correct patterning in the posterior part of each embryonic metamere1,5. It is also necessary later in development, as fused mutations lead to anomalies of adult cuticular structures and tumorous ovaries. Here we provide molecular evidence that this gene encodes a putative serine/threonine protein kinase, a new function for the product of a segmentation gene. This result provides further insight into segment-polarity interactions and their role in pattern formation.
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References
Nusslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).
Ingham, P. Nature 335, 25–34 (1988).
Di Nardo, S., Sher, E., Heemskerk-Jongens, J., Kassis, J. A. & O'Farrell, P. H. Nature 332, 604–609 (1988).
Martinez-Arias, A., Baker, N. E. & Ingham, P. W. Development 103, 157–170 (1988).
Martinez-Arias, A. J. Embryol. exp. Morphol. 87, 99–114 (1985).
Fausto-Sterling, A. Devl Biol. 63, 358–369 (1978).
Smith, P. A. & King, R. C. J. natn. Cancer Inst. 36, 445–461 (1966).
Busson, D., Limbourg-Bouchon, B., Mariol, M. C., Préat, T. & Lamour-lsnard, C. Wilhelm Roux Arch. dev. Biol. 197, 221–230 (1988).
Mariol, M. C., Préat, T. & Limbourg-Bouchon, B. Molec. cell. Biol. 7, 3244–3251 (1987).
Préat, T. Nucleic Acids Res. 18, 1073 (1990).
Hanks, S. K., Quinn, A. M. & Hunter, T. Science 241, 42–52 (1988).
Lorincz, A. T. & Reed, S. I. Nature 307, 183–185 (1984).
Russel, P. & Nurse, P. Cell 49, 569–576 (1987).
Hunter, T. Cell 50, 823–829 (1987).
Dunphy, W. G. & Newport, J. W. Cell 55, 925–928 (1988).
Lee, M. & Nurse, P. Trends Genet. 4, 287–290 (1988).
Kalderon, D. & Rubin, G. M. Genes Dev. 2, 1539–1556 (1988).
Schaeffer, E. et al. Cell 57, 403–412 (1989).
Mark, G. E. et al. Molec. cell. Biol. 7, 2134–2140 (1987).
Nishida, Y. et al. EMBO J. 7, 775–781 (1988).
Shilo, B. Z. Trends Genet. 3, 69–72 (1987).
Montell, C. & Rubin, G. Cell 52, 757–772 (1987).
Hafen, E., Basler, K., Edstroem, J. E. & Rubin, G. M. Science 236, 55–63 (1987).
Sprenger, F., Stevens, L. M. & Nusslein-Volhard, C. Nature 338, 478–483 (1989).
Ollo, R. & Maniatis, T. Proc. natn. Acad. Sci. U.S.A. 84, 5700–5704 (1987).
Krause, H. M. & Gehring, W. J. EMBO J. 8, 1197–1204 (1989).
Gay, N. J., Poole, S. J. & Kornberg, T. B. Nucleic Acids Res. 16, 6637–6647 (1988).
Fjose, A., McGinnis, W. J. & Gehring, W. J. Nature 313, 284–289 (1985).
Bopp, D., Burri, M., Baumgartner, S., Frigerio, G. & Noll, M. Cell 47, 1033–1040 (1986).
Rijsewijk, F. et al. Cell 50, 649–657 (1987).
Van den Heuvel, M., Nusse, R., Johnston, P. & Lawrence, P. A. Cell 59, 739–749 (1989).
Nakano, Y. et al. Nature 341, 508–513 (1989).
Fausto-Sterling, A. & Smith-Schless, H. Genetics 101, 71–80 (1982).
King, R. C. Ovarian Development in Drosophila melanogaster (Academic, New York, 1970).
Robertson, H. M. et al. Genetics 118, 461–470 (1988).
Sanger, F., Nicklen, S. & Coulson, R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Parker, P. J. et al. Science 233, 853–859 (1986).
Bennet, M. K. & Kennedy, M. B. Proc. natn. Acad. Sci. U.S.A. 84, 1794–1798 (1987).
Lipman, D. J. & Pearson, W. R. Science 227, 1435–1441 (1985).
Hooper, J. E. & Scott, M. P. Cell 59, 751–765 (1989).
Siegfried, E., Perkins, L. A., Capaci, T. M. & Perrimon, N. Nature 345, 825–829 (1990).
Bontouis, M. et al. EMBO J. (in the press).
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Préat, T., Thérond, P., Lamour-lsnard, C. et al. A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila. Nature 347, 87–89 (1990). https://doi.org/10.1038/347087a0
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DOI: https://doi.org/10.1038/347087a0
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