Abstract
GLOMERULONEPHRITIS is an inflammation of the kidney characterized by the accumulation of extracellular matrix within the damaged glomeruli1–4, impaired filtration and proteinuria. In its progressive form, the disease destroys kidney function leading to uraemia and death, unless dialysis therapy or kidney transplantation is available. The pathogenesis of glomerulonephritis is incompletely understood, but the eliciting factor is thought often to be an immunological injury to mesangial and/or other resident cells in the glomeruli5,6. We have used an animal model of acute mesangial proliferative glomerulonephritis7,8 to show that this disease is associated with increased production and activity of transforming growth factor β1 (TGF-βl)9, an inducer of extracellular matrix production10–17. Here we report that administration of anti-TGF-βl at the time of induction of the glomerular disease suppresses the increased production of extracellular matrix and dramatically attenuates histological manifestations of the disease. These results provide direct evidence for a causal role of TGF-βl in the pathogenesis of the experimental disease and suggest a new approach to the therapy of glomerulonephritis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bruijn, J. A., Hogendoorn, P. C., Hoedemaeker, P. J. & Fleuren, G. J. J. Lab. clin. Med. 111, 140–149 (1988).
Klahr, S., Schreiner, G. & Ichikawa, I. New Engl. J. Med. 318, 1657–1666 (1988).
Striker, L. M. M., Killen, P. D., Chi, E. & Striker, G. E. Lab. Invest. 51, 181–192 (1984).
Diamond, J. R. & Karnovsky, M. J. Kidney Int. 33, 917–924 (1988).
Couser, W. G. Kidney Int. 28, 569–583 (1985).
Andres, G., Brentjens, J. R., Caldwell, P. R., Camussi, G. & Matsuo, S. Lab. Invest. 55, 510–520 (1986).
Bagchus, W. M., Hoedemaeker, P. J., Rozing, J. & Bakker, W. W. Lab. Invest. 55, 680–687 (1986).
Yamamoto, T. & Wilson, C. B. Kidney Int. 32, 514–525 (1987).
Okuda, S., Languino, L. R., Ruoslahti, E. & Border, W. A. J. clin. Invest. (in the press).
Ignotz, R. A. & Massague, J. J. biol. Chem. 261, 4337–4345 (1986).
Roberts, A. B. et al. Proc. natn. Acad. Sci. U.S.A. 83, 4167–4171 (1986).
Massague, J. Cell 49, 437–438 (1987).
Ignotz, R. A. & Massague, J. Cell 51, 189–197 (1987).
Sporn, M. B., Roberts, A. B., Wakefield, L. M. & de Crombrugghe, B. J. Cell Biol. 105, 1039–1044 (1987).
Keski-Oja, J., Leof, E. B., Lyons, R. M., Coffey, R. J. & Moses, H. L. J. Cell Biochem. 33, 95–107 (1987).
Roberts, C. et al. J. biol. Chem. 263, 4586–4592 (1988).
Border, W. A., Okuda, S., Languino, L. R. & Ruoslahti, E. Kidney Int. 37, 689–695 (1990).
Flanders, K. C., Roberts, A. B., Ling, N., Fleurdelys, B. E. & Sporn, M. B. Biochemistry 27, 739–746 (1988).
Flanders, K. C. et al. J. Cell Biol. 108, 653–660 (1989).
Bassols, A. & Massague, J. J. biol. Chem. 263, 3039–3045 (1988).
Morales, T. I. & Roberts, A. B. J. biol. Chem. 263, 12828–12831 (1988).
Czaja, M. J. et al. J. Cell Biol. 108, 2477–2482 (1989).
MacKay, K. et al. J. clin. Invest. 82, 1160–1167 (1989).
Derynck, R. et al. Nature 316, 701–705 (1985).
Nakamura, T., Okuda, S., Miller, D., Ruoslahti, E. & Border, W. Kidney Int. 37, 221 (1990) (abstr.).
Laiho, M., Saksela, O., Andreasen, P. A. & Keski-Oja, J. J. Cell Biol. 103, 2403–2410 (1986).
Edwards, D. R. et al. EMB0 J. 6, 1899–1904 (1987).
Border, W. A. Kidney Int. 34, 419–434 (1988).
Cheifetz, S. et al. Cell 48, 409–415 (1987).
Benoit, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 917 (1982).
Raij, L., Azar, S. & Keane, W. Kidney Int. 26, 137–143 (1984).
Mauer, S. J. et al. J. clin. Invest. 74, 1143–1155 (1984).
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294–5299 (1979).
Kondaiah, P. E. et al. J. biol. Chem. 263, 18313–18317 (1988).
Fort, Ph. et al. Nucleic Acids Res. 13, 1431–1443 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Border, W., Okuda, S., Languino, L. et al. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature 346, 371–374 (1990). https://doi.org/10.1038/346371a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/346371a0
This article is cited by
-
Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?
GeroScience (2020)
-
Regenerative potential of platelets in patients with chronic kidney disease
International Urology and Nephrology (2019)
-
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Scientific Reports (2018)
-
Transforming growth factor-β in stem cells and tissue homeostasis
Bone Research (2018)
-
Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2
International Urology and Nephrology (2018)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.