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Genetic organization of a chimpanzee lentivirus related to HIV-1

Nature volume 345, pages 356–359 (1990)Cite this article

Abstract

SIMIAN immunodeficiency viruses have been isolated from four species of monkey, the 'captive' macaque1 and mangabey2–4 and the 'feral' African green monkey5 and mandrill6. While none of these viruses is a replica of HIV-1, the macaque7 and mangabey8 viruses represent correct genetic models for HIV-2, possessing exactly the same complement of genes. Recently a lentivirus has been identified in two wild chimpanzees (Pan troglodytes troglodytes) in Gabon, west equatorial Africa, and isolated from one of them9. This virus is referred to as SIVCPZ. Sera from these animals cross reacted with all the HIV-1 proteins including the envelope glycoproteins. Here, we describe the molecular cloning and sequencing of an infectious proviral clone of SIVCPZ. The overall genetic organization was the same as that of HIV-1, but phylogenetic analysis revealed that the sequence was more divergent than any HIV-1 sequence reported so far. The vpu gene product, found only in the type 1 viruses, was particularly different (64% divergent to HIV-1BRU) suggesting that the SIVCPZ represents a distinct subtype. These findings indicate that there is a larger pool of simian lentiviruses than previously suspected and revives debate as to the origins of HIV-1.

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References

  1. Daniel, M. D. et al. Science 228, 1201–1204 (1985).

    Article  ADS  CAS  Google Scholar 

  2. Lowenstine, L. J. et al. Int. J. Cancer 38, 563–574 (1986).

    Article  CAS  Google Scholar 

  3. Murphey-Corb, M. et al. Nature 321, 435–437 (1986).

    Article  ADS  CAS  Google Scholar 

  4. Fultz, P. N. et al. Proc. natn. Acad. Sci. U.S.A. 83, 5286–5290 (1986).

    Article  ADS  CAS  Google Scholar 

  5. Ohta, Y. et al. Int. J. Cancer 41, 115–122 (1988).

    Article  CAS  Google Scholar 

  6. Tsujimoto, H. et al. J. Virol. 62, 4044–4050 (1989).

    Google Scholar 

  7. Chakrabarti, L. et al. Nature 328, 543–547 (1987).

    Article  ADS  CAS  Google Scholar 

  8. Hirsch, V. M., Olmsted, R. A., Murphey-Corb, M., Purcell, R. H. & Johnson, P. R. Nature 339, 389–392 (1989).

    Article  ADS  CAS  Google Scholar 

  9. Peeters, M. et al. AIDS 3, 625–630 (1989).

    Article  CAS  Google Scholar 

  10. Cornell, C. et al. Bio Techniques 5, 342–348 (1987).

    Google Scholar 

  11. Wain-Hobson, S., Sonigo, P., Danos, O., Cole, S. & Mizon, M. Cell 40, 9–17 (1985).

    Article  CAS  Google Scholar 

  12. Alizon, M., Wain-Hobson, S., Montagnier, L. & Sonigo, P. Cell 46, 63–74 (1986).

    Article  CAS  Google Scholar 

  13. Guyader, M. et al. Nature 326, 662–669 (1987).

    Article  ADS  CAS  Google Scholar 

  14. Emerman, M., Guyader, M., Montagnier, L., Baltimore, D. & Muesing, M. EMBO J. 6, 3755–3760 (1987).

    Article  CAS  Google Scholar 

  15. Malim, M. H. et al. Proc. natn. Acad. Sci. U.S.A. 86, 8222–8226 (1989).

    Article  ADS  CAS  Google Scholar 

  16. Klimkait, T., Strebel, K., Hoggan, M. D., Martin, M. A. & Orenstein, J. M. J. Virol. 64, 621–629 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Hammerschmidt, W., Sugden, B. & Baichwal, V. R. J. Virol. 63, 2469–2475 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Gurgo, C. et al. Virology 164, 531–536 (1988).

    Article  CAS  Google Scholar 

  19. Smith, R. F. & Smith, T. F. Proc. natn. Acad. Sci. U.S.A. 87, 118–122 (1990).

    Article  ADS  CAS  Google Scholar 

  20. Smith, T. F., Srinivasan, A., Schochetman, G., Marcus, M. & Myers, G. Nature 333, 573–575 (1988).

    Article  ADS  CAS  Google Scholar 

  21. Wilbur, W. J. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 80, 726–730 (1983).

    Article  ADS  CAS  Google Scholar 

  22. Huet, T., Dazza, M. C., Brun-Vézinet, F., Roelants, G. E. & Wain-Hobson, S. AIDS 3, 707–715 (1989).

    Article  CAS  Google Scholar 

  23. Fukasawa, M. et al. Nature 333, 457–461 (1988).

    Article  ADS  CAS  Google Scholar 

  24. Tsujimoto, H. et al. Nature 341, 539–541 (1989).

    Article  ADS  CAS  Google Scholar 

  25. Chen, C. & Okayama, H. Molec. cell. Biol. 7, 2745–2752 (1987).

    Article  CAS  Google Scholar 

  26. Staden, R. Nucleic Acids Res. 10, 4731–4751 (1982).

    Article  CAS  Google Scholar 

  27. Saiki, R. K. et al. Science 239, 487–491 (1988).

    Article  ADS  CAS  Google Scholar 

  28. Kyte, J. & Doolittle, R. J. molec. Biol. 157, 105–132 (1982).

    Article  CAS  Google Scholar 

  29. Myers, G. et al. Human Retroviruses and AIDS (Los Alamos National Laboratory, New Mexico, 1989).

    Google Scholar 

  30. Felsenstein, J. A. Rev. Genet. 22, 521–565 (1988).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Georges Roelants: Centre International de Recherches Médicales de Franceville, BP 769, Franceville, Gabon

Authors and Affiliations

  1. Laboratoire de Biologie et Immunologie Moléculaires des Rétrovirus, Institut Pasteur, 28 Rue de Dr Roux, 75724, Paris, cedex 15, France

    Thierry Huet, Rémi Cheynier, Andreas Meyerhans, Georges Roelants & Simon Wain-Hobson

Authors
  1. Thierry Huet
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  2. Rémi Cheynier
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  3. Andreas Meyerhans
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  4. Georges Roelants
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  5. Simon Wain-Hobson
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Huet, T., Cheynier, R., Meyerhans, A. et al. Genetic organization of a chimpanzee lentivirus related to HIV-1. Nature 345, 356–359 (1990). https://doi.org/10.1038/345356a0

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