Abstract
In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by self-antigen exceeds a critical threshold. The tolerant state of the B cell is closely correlated with down-regulation of membrane IgM but not IgD antigen-receptors. Identical changes in antigen-receptor expression occur in a subset of follicular B cells in nontransgenic mice, suggesting that clonally silenced self-reactive cells are common in the peripheral B-cell repertoire.
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Goodnow, C., Crosbie, J., Jorgensen, H. et al. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342, 385–391 (1989). https://doi.org/10.1038/342385a0
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DOI: https://doi.org/10.1038/342385a0
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