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Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

Nature volume 339, pages 593–597 (1989)Cite this article

Abstract

The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive represser and, when coexpressed with the receptor, blocks activation by thyroid hormone. Thus, v-erbA may be the first example of a dominant negative oncogene.

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Authors and Affiliations

  1. Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California, 92138-9216, USA

    Klaus Damm, Catherine C. Thompson & Ronald M. Evans

  2. Department of Biology, University of California at San Diego, La Jolla, California, 92093, USA

    Catherine C. Thompson

Authors
  1. Klaus Damm
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  2. Catherine C. Thompson
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  3. Ronald M. Evans
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Damm, K., Thompson, C. & Evans, R. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 339, 593–597 (1989). https://doi.org/10.1038/339593a0

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