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The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

Abstract

The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.

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Acharya, R., Fry, E., Stuart, D. et al. The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution. Nature 337, 709–716 (1989). https://doi.org/10.1038/337709a0

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