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A novel cancer therapy using a Mössbauer-isotope compound

Abstract

Cancer radiotherapy uses high doses of ionizing radiation (l–102Gy; 102–104rad) because only a small fraction of the absorbed dose leads to lethal double-strand breaks in DNA. These breaks are more efficiently produced by Auger electrons (1–10 eV nm−1) generated in proximity to the DNA. The energy of these electrons (on average 21 electrons for the decay of 125I) is dissipated within 10–100 nm of the Auger event and produces multiple double-strand DNA breaks1,2. A single Auger event can be lethal to a cell and is comparable to more than 105 photon absorption events in conventional radiotherapy3,4. We now report that 57Fe(III).bleomycin, administered to malignant cells in vitro and in vivo and irradiated with resonant Mossbauer gamma rays (14.4 keV), causes ablation of the malignant cells, presumably by Auger cascade, with extremely small radiation doses—about 10−5 Gy. As a basis for comparison, about 5 Gy is necessary to achieve a similar effect with conventional radiotherapy5.

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References

  1. 1

    Charlton, D. E. & Booz, J. Radiat. Res. 87, 10–23 (1981).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Linz, U. & G. Stoecklin, G. 7th International Congress of Radiation Research (Amsterdam, 1983).

    Google Scholar 

  3. 3

    Hofer, K. G. & Hughes, W. L. Radiat. Res. 47, 94–109 (1971).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Feinendegen, L. E., Ertl, H. H. & Bond, V. P. Proc. Symp. Biophysical Aspects of Radiation Quality 419–430 (International Atomic Energy Agency, Australia 1971).

    Google Scholar 

  5. 5

    Hall, E. J. Radiology for the Radiologist 2nd edn, 225 (Harper & Row, Philadelphia, 1978).

    Google Scholar 

  6. 6

    Hannon, J. P., Carron, N. J. & Trammell, G. T. Phys. Rev. B9, 2791–2809 (1974).

    ADS  Article  Google Scholar 

  7. 7

    Paoletti, J., Magee, B. B. & Magee, P. T. Biochemistry 16, 351–357 (1977).

    CAS  Article  Google Scholar 

  8. 8

    Sakai, T. T., Riordan, J. M., Booth, T. E. & Glickson, J. D. J. Med. Chem. 24, 279–285 (1981).

    CAS  Article  Google Scholar 

  9. 9

    Povirk, L. F., Hogan, M. & Dattagupta, N. Biochemistry 18, 96–101 (1979).

    CAS  Article  Google Scholar 

  10. 10

    Rao, E. A., Saryan, L. A., Antholine, W. E. & Petering, D. H. J. Med. Chem. 23, 1310–1318 (1980).

    CAS  Article  Google Scholar 

  11. 11

    Lin, P., Kwock, L., Hefter, K. & Misslbeck, G. Cancer Res. 43, 1049–1053 (1983).

    CAS  PubMed  Google Scholar 

  12. 12

    Wu, H., N. Dattagupta, M. Hogan & Crothers, D. M. Biochemistry 19, 626–634 (1980).

    CAS  Article  Google Scholar 

  13. 13

    Lawrence, J. & Daune, M. Biochemistry 15, 3301–3307 (1976).

    CAS  Article  Google Scholar 

  14. 14

    Lawrence, J., Chan, D. C. F. & Piette, L. H. Nucleic Acids Res. 3, 2879–2893 (1976).

    CAS  Article  Google Scholar 

  15. 15

    Paoletti, C. et al. Recent Results in Cancer Research 74, 107–122 (1980).

    CAS  Article  Google Scholar 

  16. 16

    Stecher, P. G. (ed) The Merck Index 8th edn, 6 (Merck & Co., New Jersey, 1968).

  17. 17

    Clarke, E. G. C. Isolation and Identification of Drugs Vol. 1, 366 (Pharmaceutical Press, London, 1969).

    Google Scholar 

  18. 18

    Burger, R. M., Kent, T. A., Horwitz, S. B., Munck, E. & Peisach, J. J. Biol. Chem. 258, 1559–1564 (1983).

    CAS  PubMed  Google Scholar 

Download references

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Mills, R., Walter, C., Venkataraman, L. et al. A novel cancer therapy using a Mössbauer-isotope compound. Nature 336, 787–789 (1988). https://doi.org/10.1038/336787a0

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