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Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells


Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine Ml myeloid leukaemia cell line1,2. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3–5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.

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Moreau, JF., Donaldson, D., Bennett, F. et al. Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336, 690–692 (1988).

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